Schulze-Hagen Maximilian Franz, Pfeffer Jochen, Zimmermann Markus, Liebl Martin, von Stillfried Saskia Freifrau, Kuhl Christiane, Bruners Philipp, Isfort Peter
Department of Diagnostic and Interventional Radiology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Department of Pathology, University Hospital RWTH Aachen, Pauwelsstraße 30, 52074, Aachen, Germany.
Cardiovasc Intervent Radiol. 2017 Jun;40(6):924-929. doi: 10.1007/s00270-017-1597-1. Epub 2017 Feb 7.
To evaluate the feasibility of a novel curved CT-guided biopsy needle prototype with shape memory to access otherwise not accessible biopsy targets.
A biopsy needle curved by 90° with specific radius was designed. It was manufactured using nitinol to acquire shape memory, encased in a straight guiding trocar to be driven out for access of otherwise inaccessible targets. Fifty CT-guided punctures were conducted in a biopsy phantom and 10 CT-guided punctures in a swine corpse. Biposies from porcine liver and muscle tissue were separately gained using the biopsy device, and histological examination was performed subsequently.
Mean time for placement of the trocar and deployment of the inner biopsy needle was 205 ± 69 and ~93 ± 58 s, respectively, with a mean of ~4.5 ± 1.3 steps to reach adequate biopsy position. Mean distance from the tip of the needle to the target was ~0.7 ± 0.8 mm. CT-guided punctures in the swine corpse took relatively longer and required more biopsy steps (574 ± 107 and ~380 ± 148 s, 8 ± 2.6 steps). Histology demonstrated appropriate tissue samples in nine out of ten cases (90%).
Targets that were otherwise inaccessible via standard straight needle trajectories could be successfully reached with the curved biopsy needle prototype. Shape memory and preformed size with specific radius of the curved needle simplify the target accessibility with a low risk of injuring adjacent structures.
评估一种新型具有形状记忆功能的弯曲CT引导活检针原型用于获取其他方法难以触及的活检靶点的可行性。
设计了一种弯曲90°且具有特定半径的活检针。该活检针采用镍钛合金制造以获得形状记忆功能，装在一根直的引导套管针内，通过将其推出以接近其他方法难以触及的靶点。在活检模型中进行了50次CT引导穿刺，在猪尸体上进行了10次CT引导穿刺。使用该活检装置分别从猪肝和肌肉组织获取活检样本，随后进行组织学检查。
放置套管针和展开内部活检针的平均时间分别约为205±69秒和93±58秒，平均约4.5±1.3步即可到达合适的活检位置。针尖到靶点的平均距离约为0.7±0.8毫米。在猪尸体上进行的CT引导穿刺耗时相对较长，需要更多的活检步骤（分别约为574±107秒和380±148秒，8±2.6步）。组织学检查显示，10例中有9例（90%）获得了合适的组织样本。
使用这种弯曲活检针原型能够成功到达通过标准直针轨迹难以触及的靶点。弯曲针的形状记忆功能和具有特定半径的预制尺寸简化了靶点的可达性，同时损伤相邻结构的风险较低。
