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食管下段腺癌和胃食管交界腺癌的术前治疗:对随机试验当前证据的综述

Pre-operative treatments for adenocarcinoma of the lower oesophagus and gastro-oesophageal junction: a review of the current evidence from randomized trials.

作者信息

Franco Pierfrancesco, Arcadipane Francesca, Strignano Paolo, Spadi Rosella, Trino Elisabetta, Martini Stefania, Iorio Giuseppe Carlo, Satolli Maria Antonietta, Airoldi Mario, Romagnoli Renato, Camandona Michele, Ricardi Umberto

机构信息

Department of Oncology, Radiation Oncology, University of Turin, Via Genova 3, 10126, Turin, Italy.

Department of Surgical Sciences, General Surgery 2U and Liver Transplantation Center, University of Turin, Turin, Italy.

出版信息

Med Oncol. 2017 Mar;34(3):40. doi: 10.1007/s12032-017-0898-1. Epub 2017 Feb 7.

DOI:10.1007/s12032-017-0898-1
PMID:28176241
Abstract

Adenocarcinomas of the lower oesophagus and gastro-oesophageal junction are a complex clinico-pathological setting. Multimodality therapy is considered mandatory in most disease presentations. Nevertheless, the most appropriate treatment package has yet to be established. We herein summarize the evidence derived from randomized phase III trials on pre-operative treatments in this oncological scenario.

摘要

食管下段腺癌和胃食管交界腺癌是一种复杂的临床病理情况。在大多数疾病表现中,多模式治疗被认为是必不可少的。然而,最合适的治疗方案尚未确立。我们在此总结了在这种肿瘤学情况下,关于术前治疗的随机III期试验所获得的证据。

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本文引用的文献

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Preoperative therapy in locally advanced esophageal cancer.局部晚期食管癌的术前治疗。
World J Gastroenterol. 2016 Oct 21;22(39):8750-8759. doi: 10.3748/wjg.v22.i39.8750.
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Chemoradiotherapy in tumours of the oesophagus and gastro-oesophageal junction.食管癌和胃食管交界部肿瘤的放化疗
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Combined modality therapy for thoracic and head and neck cancers: a review of updated literature based on a consensus meeting.
新辅助免疫检查点阻断治疗实体恶性肿瘤的原理和新应用。
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Radiotherapy treatment strategies for squamous cell carcinoma of the cervical oesophagus: moving toward better outcomes.颈段食管癌的放射治疗策略:迈向更好的治疗效果
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Ann Oncol. 2016 Apr;27(4):660-7. doi: 10.1093/annonc/mdw010. Epub 2016 Jan 17.
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Advances in the Management of Gastric and Gastroesophageal Cancers.胃癌和胃食管癌管理的进展
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Neoadjuvant chemoradiotherapy plus surgery versus surgery alone for oesophageal or junctional cancer (CROSS): long-term results of a randomised controlled trial.新辅助放化疗联合手术与单纯手术治疗食管或食管胃交界癌(CROSS):一项随机对照临床试验的长期结果。
Lancet Oncol. 2015 Sep;16(9):1090-1098. doi: 10.1016/S1470-2045(15)00040-6. Epub 2015 Aug 5.
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Role of radiotherapy in the pre-operative management of carcinoma of the esophagus.放射治疗在食管癌术前管理中的作用。
World J Gastrointest Oncol. 2015 Jan 15;7(1):1-5. doi: 10.4251/wjgo.v7.i1.1.
8
Surgery alone versus chemoradiotherapy followed by surgery for stage I and II esophageal cancer: final analysis of randomized controlled phase III trial FFCD 9901.手术与放化疗后手术治疗Ⅰ期和Ⅱ期食管癌的比较:FFCD 9901 期随机对照Ⅲ期试验的最终分析。
J Clin Oncol. 2014 Aug 10;32(23):2416-22. doi: 10.1200/JCO.2013.53.6532. Epub 2014 Jun 30.
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Preoperative chemoradiotherapy for esophageal or junctional cancer.术前放化疗治疗食管或食管胃交界癌。
N Engl J Med. 2012 May 31;366(22):2074-84. doi: 10.1056/NEJMoa1112088.
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Lancet Oncol. 2011 Jul;12(7):681-92. doi: 10.1016/S1470-2045(11)70142-5. Epub 2011 Jun 16.