Pandey Abhishek, Yoruk Umit, Keerthivasan Mahesh, Galons Jean-Philippe, Sharma Puneet, Johnson Kevin, Martin Diego R, Altbach Maria I, Bilgin Ali, Saranathan Manojkumar
Electrical & Computer Engineering, University of Arizona, Tucson, Arizona, USA.
Medical Imaging, University of Arizona, Tucson, Arizona, USA.
J Magn Reson Imaging. 2017 Jul;46(1):303-311. doi: 10.1002/jmri.25576. Epub 2017 Feb 8.
To develop a novel multiresolution MRI methodology for accurate estimation of glomerular filtration rate (GFR) in vivo.
A three-dimensional golden-angle radial stack-of-stars (SoS) trajectory was used for data acquisition on a 3 Tesla MRI scanner. Multiresolution reconstruction and analysis was performed using arterial input function reconstructed at 1-s. temporal resolution and renal dynamic data reconstructed using compressed sensing (CS) with 4-s temporal resolution. The method was first validated using simulations and the clinical utility of the technique was evaluated by comparing the GFR estimates from the proposed method to the estimated GFR (eGFR) obtained from serum creatinine for 10 subjects.
The 4-s temporal resolution CS images minimized streaking artifacts and noise while the 1-s temporal resolution AIF minimized errors in GFR estimates. A paired t-test showed that there was no statistically significant difference between MRI based total GFR values and serum creatinine based eGFR estimates (P = 0.92).
We have demonstrated the feasibility of multiresolution MRI using a golden angle radial stack-of-stars scheme to accurately estimate GFR as well as produce diagnostic quality dynamic images in vivo.
1 Technical Efficacy: Stage 3 J. MAGN. RESON. IMAGING 2017;46:303-311.
开发一种新型多分辨率磁共振成像（MRI）方法，用于在体准确估计肾小球滤过率（GFR）。
在3特斯拉MRI扫描仪上采用三维黄金角径向星状堆叠（SoS）轨迹进行数据采集。使用以1秒时间分辨率重建的动脉输入函数以及采用4秒时间分辨率的压缩感知（CS）重建的肾脏动态数据进行多分辨率重建和分析。该方法首先通过模拟进行验证，并通过将所提方法得到的GFR估计值与10名受试者血清肌酐获得的估计肾小球滤过率（eGFR）进行比较，评估该技术的临床实用性。
4秒时间分辨率的CS图像将条纹伪影和噪声降至最低，而1秒时间分辨率的动脉输入函数将GFR估计中的误差降至最低。配对t检验显示，基于MRI的总GFR值与基于血清肌酐的eGFR估计值之间无统计学显著差异（P = 0.92）。
我们已证明采用黄金角径向星状堆叠方案的多分辨率MRI在体准确估计GFR以及生成诊断质量动态图像的可行性。
1 技术效能：3期 J.MAGN.RESON.IMAGING 2017;46:303 - 311。
