内脏脂肪与肥胖的黑人和白人青少年男孩之间肝脏脂肪的种族差异有关。
Visceral fat is associated with the racial differences in liver fat between black and white adolescent boys with obesity.
机构信息
Division of Weight Management & Wellness, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada.
出版信息
Pediatr Diabetes. 2017 Nov;18(7):660-663. doi: 10.1111/pedi.12492. Epub 2017 Feb 8.
OBJECTIVE
We examined whether racial differences in liver fat are associated with the differences in abdominal fat distribution or cardiorespiratory fitness (CRF).
METHODS
Participants included 57 black and white obese boys (12-18 years). Total and abdominal fat was measured by dual-energy X-ray absorptiometry (DXA) and magnetic resonance imaging, respectively. CRF was measured using a maximal graded treadmill test with the use of standard open-circuit spirometry techniques until volitional fatigue. Liver fat was measured using a 3T proton magnetic resonance spectroscopy. Fatty liver was defined as having liver fat ≥5%.
RESULTS
In the sample, 16.1% of black boys and 30.8% of white boys had fatty liver. Liver fat was associated (P ≤ .05) with body mass index (BMI) percentile (r = 0.28), total fat (r = 0.31), waist circumference (r = 0.38), visceral fat (r = 0.62), abdominal subcutaneous adipose tissue (r = 0.30), and CRF (r = -0.27) adjusting for age and race. White boys had greater liver fat than black boys with adjustment for age and differences in BMI percentile or CRF, but not with waist circumference or visceral fat (P > .05). In a model with age, ethnicity, total body fat, fat-free mass, visceral fat, abdominal subcutaneous fat, and CRF, visceral fat was the only factor to be independently associated with increased odds of having fatty liver (OR = 1.12; 95% CI: 1.04-1.21; P = .003).
CONCLUSION
The racial disparities in liver fat between obese black vs white adolescents are explained, in part, by differences in visceral fat.
目的
本研究旨在探讨肝脏脂肪含量的种族差异是否与腹部脂肪分布或心肺功能（cardiorespiratory fitness，CRF）的差异有关。
方法
研究纳入了 57 名肥胖的黑人和白人青少年男孩（12-18 岁）。通过双能 X 射线吸收法（dual-energy X-ray absorptiometry，DXA）和磁共振成像（magnetic resonance imaging，MRI）分别测量全身脂肪和腹部脂肪。使用标准闭路测功仪技术的最大递增跑步机测试测量 CRF，直至出现自愿疲劳。使用 3T 质子磁共振波谱法（proton magnetic resonance spectroscopy，MRS）测量肝脏脂肪。肝脏脂肪≥5%定义为脂肪肝。
结果
在该样本中，16.1%的黑人男孩和 30.8%的白人男孩患有脂肪肝。在校正年龄和种族后，肝脏脂肪与体重指数（body mass index，BMI）百分位数（r=0.28）、全身脂肪（r=0.31）、腰围（r=0.38）、内脏脂肪（r=0.62）、腹部皮下脂肪组织（r=0.30）和 CRF（r=-0.27）相关。调整 BMI 百分位数或 CRF 后，白人男孩的肝脏脂肪含量高于黑人男孩，但在校正腰围或内脏脂肪后差异无统计学意义（P＞0.05）。在一个包含年龄、种族、全身脂肪、去脂体重、内脏脂肪、腹部皮下脂肪和 CRF 的模型中，内脏脂肪是唯一与脂肪肝患病风险增加独立相关的因素（OR=1.12；95%CI：1.04-1.21；P=0.003）。
结论
肥胖的黑人和白人青少年之间肝脏脂肪的种族差异部分可以通过内脏脂肪的差异来解释。
Zotero 插件