Faasse Sarah, Braun Hayley, Vos Miriam
Health Sciences Research Building, Emory University, 1760 Haygood Drive, W-450, Atlanta, GA 30322, USA.
F1000Res. 2018 Feb 9;7:170. doi: 10.12688/f1000research.12028.1. eCollection 2018.
Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in the world, yet the complex pathogenesis remains to be fully elucidated. The prevalence of NAFLD has risen precipitously in recent years and is now a leading indication for liver transplantation. New waitlist registrants with non-alcoholic steatohepatitis-induced cirrhosis increased by 170% from 2004 to 2013. In addition, patients with NAFLD are at increased risk of both cardiovascular disease and type II diabetes. In this update, recent studies contributing to the understanding of the place of NAFLD in cardiometabolic disease will be discussed.
非酒精性脂肪性肝病(NAFLD)是全球慢性肝病最常见的病因,但其复杂的发病机制仍有待充分阐明。近年来,NAFLD的患病率急剧上升,现已成为肝移植的主要指征。2004年至2013年,因非酒精性脂肪性肝炎导致肝硬化而新加入等待名单的人数增加了170%。此外,NAFLD患者患心血管疾病和II型糖尿病的风险也增加。在本次更新中,将讨论有助于理解NAFLD在心脏代谢疾病中地位的最新研究。