Rahbar Ali Reza, Ostovar Afshin, Derakhshandeh-Rishehri Seyedeh-Masomeh, Janani Leila, Rahbar Amin
Department of Nutrition, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr. Iran.
Department of Epidemiology, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr. Iran.
Endocr Metab Immune Disord Drug Targets. 2017;17(1):5-18. doi: 10.2174/1570161115999170207113803.
Controversy persists regarding the effect of mixtures of conjugated linoleic acids (c9, t11- and t10, c12-CLA) in fasting blood glucose (FBG) and waist circumference (WC) in humans.
The aim of this meta-analysis is to explore the effect of CLA on FBG and WC.
PubMed, Google Scholar, Cochrane Library, Science Direct, Pro-Quest and Ovid were searched up to January 2015. Studies that examined the effect of CLA supplementation or foods enriched with CLA on FBG and WC in healthy adults were included. Studies in animals or unhealthy individuals and studies other than clinical trials were excluded. Of the 3,095 articles initially retrieved, 32 eligible randomized clinical trials were included in this systematic review. The mean difference and standard deviation of changes in FBG and WC in the intervention and control groups were used as effect size measures for the meta-analysis.
Subgroup analysis showed that CLA supplement consumption did not significantly influence FBG (standardized mean differences [SMD] = 0.075 mg/dL; 95% confidence interval (CI) = -0.099 to 0.249; p = 0.399) or WC (SMD = -0.149 cm; 95% CI = -0.522 to 0.225; p = 0.435). Foods enriched in CLA also showed no significant effect on FBG (SMD = 0.126 mg/dL; 95% CI = -0.100 to 0.352; p = 0.274) or WC (SMD = -0.233 cm; 95% CI = -0.625 to 0.159; p = 0.244).
We conclude that c9, t11- and t10, c12-CLA administered as a supplement or used to enrich foods does not affect FBG or WC in humans.
关于共轭亚油酸混合物（c9，t11 - 和t10，c12 - CLA）对人体空腹血糖（FBG）和腰围（WC）的影响，争议仍然存在。
本荟萃分析的目的是探讨CLA对FBG和WC的影响。
检索截至2015年1月的PubMed、谷歌学术、Cochrane图书馆、科学Direct、Pro - Quest和Ovid。纳入研究CLA补充剂或富含CLA的食物对健康成年人FBG和WC影响的研究。排除动物研究或不健康个体的研究以及非临床试验的研究。在最初检索的3095篇文章中，32项符合条件的随机临床试验被纳入本系统评价。干预组和对照组中FBG和WC变化的均值差和标准差用作荟萃分析的效应量指标。
亚组分析表明，食用CLA补充剂对FBG（标准化均值差[SMD]=0.075mg/dL；95%置信区间[CI]= - 0.099至0.249；p = 0.399）或WC（SMD = - 0.149cm；95%CI = - 0.522至0.225；p = 0.435）无显著影响。富含CLA的食物对FBG（SMD = 0.126mg/dL；95%CI = - 0.100至0.352；p = 0.274）或WC（SMD = - 0.233cm；95%CI = - 0.625至0.159；p = 0.244）也无显著影响。
我们得出结论，作为补充剂施用或用于丰富食物的c9，t11 - 和t10，c12 - CLA不会影响人体的FBG或WC。
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