Key State Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China.
Institute of Genetics and Developmental Biology, International College, University of Chinese Academy of Science, Beijing, China.
Cardiovasc Ther. 2017 Dec;35(6). doi: 10.1111/1755-5922.12275.
To undertake a systematic review and meta-analysis of prospective studies to determine the effect of conjugated linoleic acids (CLAs) supplementation on serum C-reactive protein (CRP).
PubMed-Medline, Web of Science, Cochrane Database, and Google Scholar databases were searched (up until May 2016) to identify prospective studies evaluating the impact of CLAs supplementation on serum CRP. Random-effects models meta-analysis was used for quantitative data synthesis. Sensitivity analysis was conducted using the leave-one-out method. Heterogeneity was quantitatively assessed using the I index. Systematic review registration: CRD42016038945.
From a total of 85 entries identified via searches, 14 studies were included in the final selection. The meta-analysis indicated a significant increase in serum CRP concentrations following supplementation with CLAs (weighted mean difference [WMD] 0.63 mg/dL, 95% confidence interval [95% CI] 0.13-1.13, N=21 arms, heterogeneity P=.026; I =52.3%). These findings were robust in sensitivity analyses. Random-effects meta-regression revealed that changes in serum CRP levels were independent of the dosage of CLAs supplementation (slope: -0.02; 95% CI: -0.10, 0.12; P=.889) or duration of follow-up (slope: 0.271; 95% CI: -0.05, 0.59; P=.098).
This meta-analysis suggests that CLA supplementation is associated with an increase in plasma CRP concentrations and a reduction in serum adiponectin concentrations, which indicates that CLA supplements have a proinflammatory effect. Randomized control trials with larger sample size and a longer follow-up period may be required for future investigations to provide an unequivocal answer.
系统评价和荟萃分析前瞻性研究，以确定共轭亚油酸（CLA）补充对血清 C 反应蛋白（CRP）的影响。
检索 PubMed-Medline、Web of Science、Cochrane 数据库和 Google Scholar 数据库（截至 2016 年 5 月），以确定评估 CLA 补充对血清 CRP 影响的前瞻性研究。使用随机效应模型荟萃分析进行定量数据合成。使用逐一剔除法进行敏感性分析。使用 I 指数对异质性进行定量评估。系统评价注册：CRD42016038945。
通过搜索共确定了 85 个条目，最终选择了 14 项研究。荟萃分析表明，CLA 补充后血清 CRP 浓度显著升高（加权均数差 [WMD] 0.63mg/dL，95%置信区间 [95%CI] 0.13-1.13，N=21 个臂，异质性 P=.026；I =52.3%）。这些发现经敏感性分析验证后仍然稳健。随机效应荟萃回归显示，血清 CRP 水平的变化与 CLA 补充的剂量（斜率：-0.02；95%CI：-0.10，0.12；P=.889）或随访时间（斜率：0.271；95%CI：-0.05，0.59；P=.098）无关。
本荟萃分析表明，CLA 补充与血浆 CRP 浓度升高和血清脂联素浓度降低相关，这表明 CLA 补充剂具有促炎作用。未来的研究可能需要更大样本量和更长随访时间的随机对照试验，以提供明确的答案。
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