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作为用于根除……的抗菌剂的镓掺杂碳点

Ga@C-dots as an antibacterial agent for the eradication of .

作者信息

Kumar Vijay Bhooshan, Natan Michal, Jacobi Gila, Porat Ze'ev, Banin Ehud, Gedanken Aharon

机构信息

Department of Chemistry.

Mina and Everard Goodman Faculty of Life Sciences, Bar Ilan Institute for Nanotechnology and Advanced Materials Bar-Ilan University, Ramat Gan.

出版信息

Int J Nanomedicine. 2017 Jan 23;12:725-730. doi: 10.2147/IJN.S116150. eCollection 2017.

Abstract

The opportunistic pathogen causes infections that are difficult to treat by antibiotic therapy. This research article reports on the synthesis of gallium (Ga) doped in carbon (C)-dots (Ga@C-dots) and their antimicrobial activity against free-living bacteria. The synthesis of Ga@C-dots was carried out by sonicating molten Ga (for 2.5 h) in polyethylene glycol-400, which acts as both a medium and carbon source. The resultant Ga@C-dots, having an average diameter of 9±2 nm, showed remarkably enhanced antibacterial activity compared with undoped C-dots. This was reflected by the much lower concentration of Ga doped within Ga@C-dots which was required for full inhibition of the bacterial growth. These results highlight the possibility of using Ga@C-dots as potential antimicrobial agents.

摘要

这种机会致病菌会引发难以通过抗生素治疗的感染。这篇研究文章报道了碳点(C点)掺杂镓(Ga)(Ga@C点)的合成及其对自由生活细菌的抗菌活性。Ga@C点的合成是通过在聚乙二醇-400中超声处理熔融的Ga(2.5小时)来进行的,聚乙二醇-400既是介质又是碳源。所得平均直径为9±2纳米的Ga@C点与未掺杂的C点相比,显示出显著增强的抗菌活性。这体现在完全抑制细菌生长所需的Ga@C点中掺杂的Ga浓度要低得多。这些结果凸显了将Ga@C点用作潜在抗菌剂的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fb3/5271377/5a24874fc8cb/ijn-12-725Fig1.jpg

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