Humboldt-Universität zu Berlin , Department of Chemistry, Brook-Taylor-Strasse 2, 12489 Berlin, Germany.
ACS Nano. 2017 Feb 28;11(2):1136-1141. doi: 10.1021/acsnano.7b00152. Epub 2017 Feb 8.
Surface-enhanced Raman scattering (SERS) probes and labels exploit surface-enhanced Raman signatures of specifically chosen reporter molecules and intrinsic biomolecules in the plasmonic near field of gold and silver nanostructures. They offer several advantages over other optical labels and sensors with respect to sensitivity and selectivity, mobility, and biocompatibility. Here, the multifunctionality and versatility of SERS labels that come from the vibrational spectroscopic information and their ability to act as nanoprobes of a biological environment are discussed. Surface-enhanced Raman scattering probes have the potential to become the next-generation sensor technology for monitoring cells and tissues. They improve our understanding of cellular function and will play a major role in future theranostic applications.
表面增强拉曼散射（SERS）探针和标签利用金和银纳米结构的等离子体近场中特定选择的报告分子和内源性生物分子的表面增强拉曼特征。与其他光学标签和传感器相比，它们在灵敏度和选择性、迁移率和生物相容性方面具有优势。本文讨论了 SERS 标签的多功能性和通用性，这些标签来自振动光谱信息及其作为生物环境纳米探针的能力。表面增强拉曼散射探针有望成为下一代用于监测细胞和组织的传感器技术。它们增进了我们对细胞功能的理解，并将在未来的治疗应用中发挥重要作用。
