Fruttero R, Calvino R, Aresca P, Bossa R, Galatulas I, Ninci M
Istituto di Chimica Farmaceutica e Tossicologica dell'Università, Torino, Italia.
Anticancer Res. 1989 Jul-Aug;9(4):971-2.
Synthesis of aryl and heteroarylazocyanides, azoxyesters and azoxysulphones, was carried out by the action of appropriate reagents on the corresponding nitroso derivatives and arylazoxyamides were obtained by hydrolysis of the corresponding azoxycyanides. Cytotoxic activity was assessed utilizing cultured P388 leukemia cells. Most of the compounds tested showed a marked cytotoxicity at concentrations below 1 micrograms/ml.
通过适当试剂作用于相应的亚硝基衍生物来合成芳基和杂芳基偶氮腈、偶氮氧基酯和偶氮氧基砜，通过相应偶氮氧基腈的水解得到芳基偶氮氧基酰胺。利用培养的P388白血病细胞评估细胞毒性活性。大多数测试化合物在浓度低于1微克/毫升时显示出明显的细胞毒性。
