芳基和杂芳基 - ONN - 偶氮氰化物的体外细胞毒性活性
In vitro cytotoxic activity of aryl and heteroaryl-ONN-azoxycyanides.
作者信息
Fruttero R, Calvino R, Di Stilo A, Gasco A, Galatulas I, Bossa R
机构信息
Dipartimento di Scienza e Tecnologia del Farmaco, Università di Torino, Italia.
出版信息
Pharmazie. 1988 Jul;43(7):499-500.
PMID:3222284
Abstract
Some aryl-N(O) = N-X and heteroaryl-N(O) = N-CN compounds were synthetized and tested against a culture of HeLa cells. The results obtained show that the - N(O) = N beta CN function, a new cytostatic group, is useful in the design of potential antitumoral compounds.
摘要
合成了一些芳基-N(O)=N-X和杂芳基-N(O)=N-CN化合物，并针对HeLa细胞培养物进行了测试。所获得的结果表明，-N(O)=NβCN官能团作为一种新的细胞生长抑制剂基团，在潜在抗肿瘤化合物的设计中很有用。
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