脂质代谢为癌症扩散提供燃料。
Lipid Metabolism Fuels Cancer's Spread.
机构信息
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
出版信息
Cell Metab. 2017 Feb 7;25(2):228-230. doi: 10.1016/j.cmet.2017.01.016.
PMID:28178563
Abstract
The ability to prospectively identify metastasis-initiating cells is essential for developing new anti-metastasis therapeutics. In a recent issue of Nature, Pascual et al. (2017) demonstrate that the fatty acid receptor CD36 marks a subpopulation of cancer cells with unique metastasis-initiating potential, highlighting a key role of lipid metabolism in metastatic colonization.
摘要
前瞻性地识别转移起始细胞对于开发新的抗转移治疗方法至关重要。在最近一期的《自然》杂志上，Pascual 等人（2017）表明，脂肪酸受体 CD36 标记了具有独特转移起始潜力的癌细胞亚群，突出了脂质代谢在转移定植中的关键作用。
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