Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA.
Cell Metab. 2017 Feb 7;25(2):228-230. doi: 10.1016/j.cmet.2017.01.016.
The ability to prospectively identify metastasis-initiating cells is essential for developing new anti-metastasis therapeutics. In a recent issue of Nature, Pascual et al. (2017) demonstrate that the fatty acid receptor CD36 marks a subpopulation of cancer cells with unique metastasis-initiating potential, highlighting a key role of lipid metabolism in metastatic colonization.
前瞻性地识别转移起始细胞对于开发新的抗转移治疗方法至关重要。在最近一期的《自然》杂志上，Pascual 等人（2017）表明，脂肪酸受体 CD36 标记了具有独特转移起始潜力的癌细胞亚群，突出了脂质代谢在转移定植中的关键作用。
