Pulido-Moran M, Bullon P, Morillo J M, Battino M, Quiles J L, Ramirez-Tortosa MCarmen
Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology "José Mataix", Biomedical Research Center, University of Granada, Granada, Spain.
Department of Periodontology, Dental School, University of Seville, Seville, Spain.
Arch Oral Biol. 2017 May;77:62-67. doi: 10.1016/j.archoralbio.2017.01.023. Epub 2017 Feb 1.
To examine the insulin resistance measured by surrogate indices in subjects with and without periodontitis and to find out any correlation among dietary intake with insulin resistance.
Fifty-five patients were recruited to participate in this cross-sectional study. Insulin resistance measured by the homoeostasis model assessment (HOMA-IR) and the quantitative insulin sensitivity check index moreover glycaemia, creatinine, uric acid, high density lipoproteins, low density lipoproteins, very low density lipoproteins and triglycerides among others. True periodontal disease was elucidated through the examination of probing pocket depth, clinical attachment level, recession of the gingival margin and gingival bleeding. The statistical analyses used were the student's T-test for independent variables, Kolmogorov-Smirnov if variations were homogeneous; if not, the Mann-Whitney U Test was applied instead. Correlations between variables were assessed using Pearson's correlation coefficients. True periodontal disease was confirmed through the greater values of probing pocket depth, clinical attachment level, gingival margin and gingival bleeding in the periodontitis group in comparison with non-periodontitis group.
Insulin resistance was evidenced by the greater values of HOMA-IR as well as by the lower quantitative insulin sensitivity check index values in the periodontitis group. Fasting insulin, glucose, uric acid, creatinine, low density lipoproteins, triglycerides and very low density lipoprotein levels were significant higher in periodontitis group. Pearson's correlations did not show any association among diet data and insulin resistance parameters in periodontitis patients.
A putative systemic relationship between insulin resistance and periodontitis exists but it does not seem conceivable any effect of diet over such relationship.
通过替代指标检查患有和未患有牙周炎的受试者的胰岛素抵抗情况，并找出饮食摄入与胰岛素抵抗之间的相关性。
招募了55名患者参与这项横断面研究。通过稳态模型评估（HOMA-IR）和定量胰岛素敏感性检查指数测量胰岛素抵抗，此外还测量血糖、肌酐、尿酸、高密度脂蛋白、低密度脂蛋白、极低密度脂蛋白和甘油三酯等。通过检查探诊深度、临床附着水平、牙龈边缘退缩和牙龈出血来明确真正的牙周疾病。所使用的统计分析方法为：对于自变量采用学生t检验，若变量变化均匀则采用柯尔莫哥洛夫-斯米尔诺夫检验；若不均匀，则改用曼-惠特尼U检验。使用皮尔逊相关系数评估变量之间的相关性。与非牙周炎组相比，牙周炎组探诊深度、临床附着水平、牙龈边缘和牙龈出血的值更高，从而证实了真正的牙周疾病。
牙周炎组HOMA-IR值较高以及定量胰岛素敏感性检查指数值较低，证明存在胰岛素抵抗。牙周炎组空腹胰岛素、血糖、尿酸、肌酐、低密度脂蛋白、甘油三酯和极低密度脂蛋白水平显著更高。皮尔逊相关性分析未显示牙周炎患者的饮食数据与胰岛素抵抗参数之间存在任何关联。
胰岛素抵抗与牙周炎之间可能存在系统性关系，但饮食对这种关系的任何影响似乎都不可想象。
