Song Jun-Long, Chen Chuang, Yuan Jing-Ping, Li Juan-Juan, Sun Sheng-Rong
Department of Breast and Thyroid Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.
Department of Pathology, Renmin Hospital of Wuhan University, Wuhan, Hubei, 430060, PR China.
Breast. 2017 Apr;32:130-134. doi: 10.1016/j.breast.2017.01.016. Epub 2017 Feb 5.
Whether a first-degree family history of others cancers (FHOC) than breast or ovarian cancer (BOC) is associated with breast cancer prognosis remains unknown. Thus, the aim of the present study was to clarify this issue.
Women who were diagnosed with invasive breast cancer at the Renmin Hospital of Wuhan University from 2010 to 2013 were included in the study. The demographic and clinicopathological characteristics of these patients were extracted. FHOC was considered positive for any patient who had a relative who had been diagnosed with cancer other than BOC. Disease-free survival (DFS) was calculated based on the date of diagnosis. DFS was analyzed using the Cox proportional hazards model.
A total of 434 breast cancer patients were included in this study. Among these patients, 61 (14.06%) had a positive FHOC in first-degree relatives. Patients with a positive FHOC tended to have HER2-positive breast cancer (p = 0.03). In the survival analysis, FHOC was associated with poor DFS in both univariate (HR = 2.21 (1.28-3.83), 95% CI: 1.28-3.83, p < 0.01) and multivariate (HR = 2.50, 95% CI: 1.24-5.04, p = 0.01) analyses, especially in patients with luminal A subtypes.
The results demonstrated an increased risk of recurrence in breast cancer patients with FHOC, especially in patients with luminal A subtype.
除乳腺癌或卵巢癌（BOC）外的其他癌症一级家族史（FHOC）是否与乳腺癌预后相关尚不清楚。因此，本研究的目的是阐明这一问题。
纳入2010年至2013年在武汉大学人民医院被诊断为浸润性乳腺癌的女性。提取这些患者的人口统计学和临床病理特征。对于任何有亲属被诊断患有除BOC以外癌症的患者，FHOC被视为阳性。无病生存期（DFS）根据诊断日期计算。使用Cox比例风险模型分析DFS。
本研究共纳入434例乳腺癌患者。在这些患者中，61例（14.06%）一级亲属的FHOC呈阳性。FHOC阳性的患者倾向于患有HER2阳性乳腺癌（p = 0.03）。在生存分析中，单因素（HR = 2.21（1.28 - 3.83），95%CI：1.28 - 3.83，p < 0.01）和多因素（HR = 2.50，95%CI：1.24 - 5.04，p = 0.01）分析中，FHOC均与较差的DFS相关，尤其是在腔面A型亚型患者中。
结果表明，FHOC的乳腺癌患者复发风险增加，尤其是腔面A型亚型患者。
