Rigakos Georgios, Liakou Chrysoula I, Felipe Naillid, Orkoulas-Razis Dennis, Razis Evangelia
Third Oncology Department, Hygeia Hospital, Marousi, Athens, Greece.
Boston University School of Medicine, Boston, MA.
Cancer Control. 2017 Jan;24(1):9-21. doi: 10.1177/107327481702400103.
Neoplastic meningitis is a complication of solid and hematological malignancies. It consists of the spread of malignant cells to the leptomeninges and subarachnoid space and their dissemination within the cerebrospinal fluid.
A literature review was conducted to summarize the clinical presentation, differential diagnosis, laboratory values, and imaging findings of neoplastic meningitis.
Neoplastic meningitis is an event in the course of cancer with a variable clinical presentation and a wide differential diagnosis. In general, characteristic findings on gadolinium-enhanced magnetic resonance imaging and the presence of malignant cells in the cerebrospinal fluid remain the cornerstones of diagnosis. However, both modalities do not always confirm the diagnosis of neoplastic meningitis despite a typical clinical picture.
Clinicians treating patients with cancer should be aware of the possibility of neoplastic meningitis, especially when multilevel neurological symptoms are present. Neoplastic meningitis can be an elusive diagnosis, so clinician awareness is important so that this malignant manifestation is recognized in a timely manner.
肿瘤性脑膜炎是实体瘤和血液系统恶性肿瘤的一种并发症。它由恶性细胞扩散至软脑膜和蛛网膜下腔并在脑脊液中播散构成。
进行文献综述以总结肿瘤性脑膜炎的临床表现、鉴别诊断、实验室检查值及影像学表现。
肿瘤性脑膜炎是癌症病程中的一个事件，临床表现多样，鉴别诊断范围广。一般来说，钆增强磁共振成像的特征性表现及脑脊液中存在恶性细胞仍是诊断的基石。然而，尽管临床表现典型，但这两种方法并不总能确诊肿瘤性脑膜炎。
治疗癌症患者的临床医生应意识到肿瘤性脑膜炎的可能性，尤其是当出现多级神经症状时。肿瘤性脑膜炎可能难以诊断，因此临床医生的意识很重要，以便及时识别这种恶性表现。
