Eskelinen Matti, Korhonen Riika, Selander Tuomas, Ollonen Paula
Department of Surgery, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
Department of Surgery, School of Medicine, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Anticancer Res. 2017 Feb;37(2):819-824. doi: 10.21873/anticanres.11383.
The Beck Depression Inventory (BDI) is one of the most widely used instruments for measuring the severity of depression. However, there has been no prospective study to investigate the long-term outcome in patients admitted to Breast Cancer Diagnosis Units.
In the Kuopio Breast Cancer Study, women with breast symptoms were evaluated for total BDI score before any diagnostic procedures were carried out. The relapse-free survival (RFS) was calculated from the time of diagnosis to the time of first relapse including local relapse, contralateral breast cancer (BC) or metastatic disease. The overall survival (OS) was assessed as the time from the date of diagnosis to the date of last follow-up or death of the patient. The effect of the BDI on the RFS and on the OS were calculated by the Kaplan-Meier survival analysis and the difference between the groups was assessed by the log-rank test. The RFS and OS was estimated for the study groups with a low BDI score (<8) versus those with a high BDI score (≥8). The end-point of our study was to determine differences in long-term outcome and in BDI score in individuals with BC, benign breast disease (BBD) and in healthy study subjects (HSS).
In the Cox proportional hazard model, the total BDI score significantly predicted the 25-year RFS and OS in the HSS, BBD and BC groups combined (Hazard Ratio=1.87, p=0.039; Hazard Ratio=1.98, p=0.048, respectively), and in the Kaplan-Meier survival analysis with the log-rank test, the total BDI score predicted the 25-year RFS and OS in the HSS, BBD and BC groups combined (p=0.043; p=0.036, respectively).
The BDI is a significant predictor of long-term outcome among patients admitted to the Breast Cancer Diagnosis Unit in Finland.
贝克抑郁量表（BDI）是测量抑郁严重程度最广泛使用的工具之一。然而，尚无前瞻性研究调查乳腺癌诊断科室收治患者的长期预后情况。
在库奥皮奥乳腺癌研究中，有乳房症状的女性在进行任何诊断程序之前接受了BDI总分评估。无复发生存期（RFS）从诊断时间计算至首次复发时间，包括局部复发、对侧乳腺癌（BC）或转移性疾病。总生存期（OS）评估为从诊断日期到患者最后一次随访或死亡的时间。BDI对RFS和OS的影响通过Kaplan-Meier生存分析计算，组间差异通过对数秩检验评估。对BDI评分低（<8）的研究组与BDI评分高（≥8）的研究组的RFS和OS进行了估计。我们研究的终点是确定患有BC、良性乳腺疾病（BBD）的个体以及健康研究对象（HSS）在长期预后和BDI评分方面的差异。
在Cox比例风险模型中，BDI总分在HSS、BBD和BC组合并时显著预测了25年的RFS和OS（风险比分别为1.87，p = 0.039；风险比为1.98，p = 0.048），在采用对数秩检验的Kaplan-Meier生存分析中，BDI总分在HSS、BBD和BC组合并时预测了25年的RFS和OS（分别为p = 0.043；p = 0.036）。
BDI是芬兰乳腺癌诊断科室收治患者长期预后的重要预测指标。
