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[5岁以下供体的肾脏用于移植:如何使用?]

[Kidneys from donors less than 5 years of age for transplantation: how to use them?].

作者信息

Robles N R, Gómez Campdera F J, Anaya F, Albertos J, Valderrábano F

出版信息

Arch Esp Urol. 1989 Jul-Aug;42(6):545-8.

PMID:2817985
Abstract

We evaluated the results of 27 renal transplants (RT) from donors less than 5 years of age (mean 2.1 +/- 1.1 years). Seven were transplanted en bloc and the rest separately. Fourteen recipients were children and 13 were adults. The overall graft survival at one year was 51%. Kidneys from donors less than 2 years of age that had not been transplanted en bloc had a survival rate of 21%. There was a marked improvement in the one-year graft survival (71%) for kidneys from donors under 2 years of age that had been transplanted en bloc, and a slight improvement (53%) for those from donors over 2 years of age. No urological complications were observed. Five RT were lost due to vascular complications. Good renal graft function was observed in both children (mean plasma creatinine 1.65 mg/dl.) and adults (mean plasma creatinine 1.90 mg/dl.). The one-year graft survival rate was 59% for the adult recipients and 42% for the children. We can conclude from these findings that kidneys from pediatric donors can be transplanted to children as well as adults and should probably be performed en bloc when the donor is less than 2 years of age.

摘要

我们评估了27例来自年龄小于5岁(平均2.1±1.1岁)供体的肾移植(RT)结果。7例进行了整块移植,其余为单独移植。14名受者为儿童,13名为成人。1年时的总体移植物存活率为51%。未进行整块移植的2岁以下供体的肾脏存活率为21%。对于进行了整块移植的2岁以下供体的肾脏,1年移植物存活率有显著提高(71%),而对于2岁以上供体的肾脏则有轻微提高(53%)。未观察到泌尿系统并发症。5例肾移植因血管并发症失败。儿童(平均血浆肌酐1.65mg/dl)和成人(平均血浆肌酐1.90mg/dl)均观察到良好的肾移植物功能。成人受者的1年移植物存活率为59%,儿童为42%。从这些结果我们可以得出结论,小儿供体的肾脏可以移植给儿童和成人,并且当供体小于2岁时可能应进行整块移植。

相似文献

1
[Kidneys from donors less than 5 years of age for transplantation: how to use them?].[5岁以下供体的肾脏用于移植:如何使用?]
Arch Esp Urol. 1989 Jul-Aug;42(6):545-8.
2
[Transplantation of kidneys from children].[儿童肾脏移植]
Helv Chir Acta. 1989 Dec;56(4):531-4.
3
Outcome of renal transplants from pediatric donors <5 yr of age.5岁以下小儿供体肾移植的结果
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4
Transplantation of pediatric en bloc cadaver kidneys into adult recipients: a single-center experience.小儿整块尸体肾脏移植给成年受者:单中心经验
Am Surg. 2002 Oct;68(10):857-9.
5
Limitations of pediatric donor kidneys for transplantation.小儿供肾用于移植的局限性。
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6
Donor factors.供体因素。
Clin Transpl. 1994:381-94.
7
Renal transplantation from donors aged < 6 years into children yields equal graft survival when compared to older donors.与年龄较大的供体相比,将6岁以下供体的肾脏移植给儿童,移植物存活率相同。
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The UNOS scientific renal transplant registry. United Network for Organ Sharing.美国器官共享联合网络(UNOS)的科学肾脏移植登记处。
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En bloc kidney transplantation from pediatric donors: comparable outcomes with living donor kidney transplantation.小儿供者整块肾脏移植:与活体供者肾脏移植相当的结果。
Transplantation. 2011 Sep 15;92(5):564-9. doi: 10.1097/TP.0b013e3182279107.