Diabetes and Bone network, Department Endocrinology and Diabetes, University Campus Bio-Medico of Rome, Via Alvaro del Portillo, 21 - 00128, Rome, Italy.
Department of Experimental Medicine, Polo Pontino, Sapienza University of Rome, Rome, Italy.
Calcif Tissue Int. 2017 Feb;100(2):122-132. doi: 10.1007/s00223-016-0226-3. Epub 2017 Feb 8.
It has been well established that bone fragility is one of the chronic complications of diabetes mellitus, and both type 1 and type 2 diabetes are risk factors for fragility fractures. Diabetes may negatively affect bone health by unbalancing several pathways: bone formation, bone resorption, collagen formation, inflammatory cytokine, muscular and incretin system, bone marrow adiposity and calcium metabolism. The purpose of this narrative review is to explore the current understanding of pathophysiological pathways underlying bone fragility in diabetics. In particular, the review will focus on the peculiar cellular and molecular system impairment that may lead to increased risk of fracture in type 1 and type 2 diabetes.
众所周知，骨质疏松症是糖尿病的慢性并发症之一，1 型和 2 型糖尿病都是脆性骨折的危险因素。糖尿病可能通过破坏以下几种途径对骨骼健康产生负面影响：骨形成、骨吸收、胶原形成、炎性细胞因子、肌肉和肠促胰岛素系统、骨髓脂肪和钙代谢。本综述旨在探讨目前对糖尿病患者骨骼脆弱的病理生理途径的认识。特别是，该综述将重点讨论可能导致 1 型和 2 型糖尿病骨折风险增加的特殊细胞和分子系统损伤。
