Apter A J, Greenberger P A, Patterson R
Department of Medicine, Northwestern University Medical School, Chicago, Ill.
Arch Intern Med. 1989 Nov;149(11):2571-5.
Asthma in adolescent pregnancies is not rare and may make patient management difficult, especially since mortality from asthma is of particular concern in the adolescent age group. We present a series of 21 pregnant adolescents with severe asthma. During 28 pregnancies, there were 56 exacerbations of asthma, including 22 hospitalizations and 20 emergency room visits. For 18 (64%) of the 28 pregnancies, outpatient systemic corticosteroids were administered, and inhaled corticosteroids were prescribed for 8 (29%). Factors associated with exacerbations included respiratory tract infections (59%) and noncompliance with medical regimens (27%). There were no maternal or fetal deaths or evidence for intrauterine growth retardation. Two infants were premature, with one experiencing acute respiratory distress syndrome. Aggressive treatment of asthma and associated respiratory tract infections, as well as careful ambulatory care, to encourage patient compliance are advisable to achieve a favorable maternal-fetal outcome.
青少年妊娠合并哮喘并不罕见，这可能会给患者管理带来困难，特别是考虑到哮喘导致的死亡率在青少年年龄组中尤为令人担忧。我们报告了21例患有重度哮喘的妊娠青少年病例。在28次妊娠期间，哮喘发作56次，包括22次住院和20次急诊就诊。在28次妊娠中的18次（64%），给予了门诊全身用糖皮质激素治疗，8次（29%）开具了吸入用糖皮质激素处方。与发作相关的因素包括呼吸道感染（59%）和不遵守医疗方案（27%）。没有孕产妇或胎儿死亡，也没有宫内生长受限的证据。两名婴儿早产，其中一名患有急性呼吸窘迫综合征。积极治疗哮喘及相关呼吸道感染，并进行仔细的门诊护理以鼓励患者依从性，对于实现良好的母婴结局是可取的。
