Gassman Natalie R
University of South Alabama Mitchell Cancer Institute, Mobile, Alabama, 36604-1405.
Environ Mol Mutagen. 2017 Mar;58(2):60-71. doi: 10.1002/em.22072. Epub 2017 Feb 9.
Bisphenol A (BPA) has become a target of intense public scrutiny since concerns about its association with human diseases such as obesity, diabetes, reproductive disorders, and cancer have emerged. BPA is a highly prevalent chemical in consumer products, and human exposure is thought to be ubiquitous. Numerous studies have demonstrated its endocrine disrupting properties and attributed exposure with cytotoxic, genotoxic, and carcinogenic effects; however, the results of these studies are still highly debated and a consensus about BPA's safety and its role in human disease has not been reached. One of the contributing factors is a lack of molecular mechanisms or modes of action that explain the diverse and pleiotropic effects observed after BPA exposure. The increase in BPA research seen over the last ten years has resulted in more studies that examine molecular mechanisms and revealed links between BPA-induced oxidative stress and human disease. Here, a review of the current literature examining BPA exposure and the induction of reactive oxygen species (ROS) or oxidative stress will be provided to examine the landscape of the current BPA literature and provide a framework for understanding how induction of oxidative stress by BPA may contribute to the pleiotropic effects observed after exposure. Environ. Mol. Mutagen. 58:60-71, 2017. © 2017 Wiley Periodicals, Inc.
自人们开始关注双酚A（BPA）与肥胖、糖尿病、生殖紊乱和癌症等人类疾病的关联以来，它已成为公众密切关注的焦点。双酚A是消费品中一种高度普遍的化学物质，人们认为人类普遍接触到该物质。众多研究已证实其具有内分泌干扰特性，并将接触双酚A与细胞毒性、基因毒性和致癌作用联系起来；然而，这些研究结果仍存在激烈争议，尚未就双酚A的安全性及其在人类疾病中的作用达成共识。一个促成因素是缺乏分子机制或作用方式来解释双酚A暴露后观察到的多样且多效性的影响。过去十年间双酚A研究的增加导致了更多研究分子机制的研究，并揭示了双酚A诱导的氧化应激与人类疾病之间的联系。在此，将对当前研究双酚A暴露以及活性氧（ROS）诱导或氧化应激的文献进行综述，以审视当前双酚A文献的概况，并提供一个框架来理解双酚A诱导的氧化应激如何可能导致暴露后观察到的多效性影响。《环境与分子突变》58:60 - 71, 2017。© 2017威利期刊公司。
