印度维持性血液透析患者的成纤维细胞生长因子-23水平
Fibroblast growth factor-23 levels in maintenance hemodialysis patients in India.
作者信息
Anandh U, Mandavkar P, Das B, Rao S
机构信息
Department of Nephrology, Yashoda Hospitals, Secunderabad, Telangana, India.
Department of Biochemistry and Immunology, Kokilaben Dhirubhai Ambani Hospital, Mumbai, Maharashtra, India.
出版信息
Indian J Nephrol. 2017 Jan-Feb;27(1):9-12. doi: 10.4103/0971-4065.177137.
Fibroblast growth factor-23 (FGF-23) levels start rising early in patients with chronic kidney disease and is implicated in cardiovascular and overall mortality of hemodialysis patients. We conducted a prospective observational cohort study in stable dialysis patients looking into the levels of FGF-23 in hemodialysis patients and its association with various demographic and biochemical variables and mortality. A total of 91 patients were enrolled in the study. The mean FGF-23 levels were very high (1152.7 pg/ml). FGF-23 levels were significantly associated with serum phosphorus and parathyroid hormone (PTH) levels in univariate and multivariate analysis. No significant association between FGF-23 and cardiovascular comorbidities and overall mortality was seen. FGF-23 levels rise exponentially in maintenance hemodialysis patients. There is a strong association between FGF-23 and phosphorus and PTH levels. No association between FGF-23 and mortality was noted in our patients.
成纤维细胞生长因子-23（FGF-23）水平在慢性肾病患者中早期就开始升高，并且与血液透析患者的心血管疾病及全因死亡率有关。我们对稳定透析患者进行了一项前瞻性观察队列研究，以探究血液透析患者的FGF-23水平及其与各种人口统计学和生化变量以及死亡率的关联。共有91名患者纳入该研究。FGF-23的平均水平非常高（1152.7 pg/ml）。在单因素和多因素分析中，FGF-23水平与血清磷和甲状旁腺激素（PTH）水平显著相关。未观察到FGF-23与心血管合并症及全因死亡率之间存在显著关联。在维持性血液透析患者中，FGF-23水平呈指数上升。FGF-23与磷和PTH水平之间存在密切关联。在我们的患者中未发现FGF-23与死亡率之间存在关联。
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