Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Kidney Int. 2010 Nov;78(10):947-9. doi: 10.1038/ki.2010.281.
In the past 40 years, disordered mineral metabolism has been among the most intensely studied areas of nephrology. A June 2010 PubMed search for 'secondary hyperparathyroidism and kidney disease' yielded 5866 references. Among these are papers documenting the development and application of numerous therapeutic agents-including calcitriol, vitamin D analogs, phosphate binders, and cinacalcet-that remain in widespread use in the day-to-day management of dialysis patients worldwide. However, almost 6000 papers later, fundamental pathophysiological concepts remain unclear, particularly regarding the early pathogenesis of disordered mineral metabolism.
在过去的 40 年中，矿物质代谢紊乱一直是肾脏病学中研究最深入的领域之一。2010 年 6 月在 PubMed 上以“继发性甲状旁腺功能亢进和肾脏疾病”为关键词进行搜索，得到了 5866 篇参考文献。其中包括描述多种治疗药物（包括骨化三醇、维生素 D 类似物、磷酸盐结合剂和西那卡塞）的开发和应用的论文，这些药物在全球范围内仍广泛用于透析患者的日常治疗。然而，在发表了近 6000 篇论文之后，基本的病理生理学概念仍然不清楚，特别是关于矿物质代谢紊乱的早期发病机制。
