Kennedy W R, Navarro X
Department of Neurology, University of Minnesota, Minneapolis.
Arch Neurol. 1989 Nov;46(11):1182-6. doi: 10.1001/archneur.1989.00520470036023.
Sympathetic nerve function was studied by the Silastic mold technique and by evaporimetry in the hand and the foot in 357 type I diabetic patients. The number of active sweat glands was below normal in 24% of patients in the hand and in 56% in the foot, while the sweat evaporation rate was low in 17% and 40% of patients, respectively. Computerized analysis of the molds, which allowed automatic sweat gland counts and estimations of the secretion volume of each sweat gland, detected abnormalities in 36% and 60% of patients. The Silastic imprint technique was found to be a sensitive test for detection of sympathetic nerve involvement, even in asymptomatic patients with normal clinical and nerve conduction examinations. Its sensitivity and accuracy has been enhanced by the computerized analysis of the molds.
采用硅橡胶模技术和蒸发测定法，对357例Ⅰ型糖尿病患者的手部和足部交感神经功能进行了研究。手部24%的患者和足部56%的患者活动汗腺数量低于正常水平，而手部和足部患者中分别有17%和40%的患者汗液蒸发率较低。对模具进行计算机分析，可自动计数汗腺并估算每个汗腺的分泌量，结果发现36%和60%的患者存在异常。即使是临床和神经传导检查正常的无症状患者，硅橡胶印记技术也被发现是检测交感神经受累的一项敏感试验。对模具的计算机分析提高了该技术的敏感性和准确性。
