Kennedy W R, Sakuta M, Sutherland D, Goetz F C
Neurology. 1984 Jun;34(6):758-63. doi: 10.1212/wnl.34.6.758.
A method that measures the amount of sweat evaporating from the skin was used to quantitate the sweating deficiency that accompanies diabetic neuropathy. The decreased amount of sweat secreted after pilocarpine stimulation was proportional to the reduction in number of excitable sweat glands, and to the decrease in water measured by the summed volume of all sweat droplets secreted. The results also correlated favorably with the degree of sensory loss to painful stimuli, but not to the alpha motor nerve conduction velocity or motor axon loss evaluated by muscle action potentials evoked from foot muscles. Respiratory-cardiovascular reflexes, as measured by the Valsalva ratio, were always abnormal in patients with demonstrated sweating deficiency and often in patients with normal sweat function.
一种测量皮肤汗液蒸发量的方法被用于量化糖尿病性神经病变伴随的出汗不足情况。毛果芸香碱刺激后分泌的汗液量减少与可兴奋汗腺数量的减少以及所有分泌的汗滴总体积所测量的水分减少成比例。这些结果也与对疼痛刺激的感觉丧失程度密切相关，但与通过足部肌肉诱发的肌肉动作电位评估的α运动神经传导速度或运动轴突损失无关。通过瓦尔萨尔瓦比率测量的呼吸 - 心血管反射在有出汗不足表现的患者中总是异常的，在汗液功能正常的患者中也常常如此。
