Peterson Rhett L, Parkinson Kate C, Mason Jeffrey B
Department of Animal, Dairy and Veterinary Sciences, Center for Integrated BioSystems, School of Veterinary Medicine, Utah State University, 4700 Old Main Hill, Logan, UT 84322, USA.
Reprod Fertil Dev. 2017 Sep;29(10):2052-2059. doi: 10.1071/RD16333.
Proper immune functioning is necessary to maximize reproductive success. In addition, age-associated uremia in women is often associated with hypothalamic--pituitary-gonadal dysfunction. In the present experiments, we tested immune and renal function to determine if exposure of postreproductive mice to young, reproductively cycling ovaries would influence non-reproductive physiological functions. Control female CBA/J mice were evaluated at 6, 13 and 16 months of age. Additional mice received new (60-day-old) ovaries at 12 months of age and were evaluated at 16 months of age. Consequently, 6-month-old control mice and 16-month-old recipient mice both possessed 6-month-old ovaries and were reproductively cycling. A significant age-related decline in immune function (T-cell subset analysis) was found in 16-month-old mice, but was improved 64% by ovarian transplantation. Renal function (blood urea nitrogen:creatinine ratio) was also decreased with aging, but ovarian transplantation restored function to levels found in 6-month-old mice. In summary, we have shown that immune and renal function, which are negatively influenced by aging, can be positively influenced or restored by re-establishment of active ovarian function in aged female mice. These findings provide a strong incentive for further investigation of the positive influence of young ovaries on restoration of health in postreproductive females.
正常的免疫功能对于实现最大生殖成功率是必要的。此外，女性与年龄相关的尿毒症常与下丘脑 - 垂体 - 性腺功能障碍有关。在本实验中，我们测试了免疫和肾功能，以确定将生殖后的小鼠暴露于年轻的、处于生殖周期的卵巢是否会影响非生殖生理功能。对雌性CBA/J对照小鼠在6、13和16月龄时进行评估。另外的小鼠在12月龄时接受新的（60日龄）卵巢，并在16月龄时进行评估。因此，6月龄的对照小鼠和16月龄的受体小鼠都拥有6月龄的卵巢且处于生殖周期。在16月龄小鼠中发现免疫功能（T细胞亚群分析）有显著的与年龄相关的下降，但卵巢移植使其改善了64%。肾功能（血尿素氮：肌酐比值）也随着衰老而降低，但卵巢移植将功能恢复到了6月龄小鼠的水平。总之，我们已经表明，衰老对其有负面影响的免疫和肾功能，可以通过在老年雌性小鼠中重新建立活跃的卵巢功能而受到积极影响或恢复。这些发现为进一步研究年轻卵巢对生殖后女性健康恢复的积极影响提供了强大的动力。
