Rim Tyler Hyungtaek, Kang Min Jae, Choi Moonjung, Seo Kyoung Yul, Kim Sung Soo
Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Korea.
Department of Ophthalmology, National Health Insurance Service Ilsan Hospital, Gyeonggi-do, Korea.
Clin Exp Ophthalmol. 2017 Jul;45(5):448-454. doi: 10.1111/ceo.12929. Epub 2017 Mar 28.
Blepharitis is one of the most common conditions. However, no study has yet evaluated the epidemiology by evaluating a large population-based sample.
To evaluate the incidence and prevalence of clinically diagnosed blepharitis in South Korea.
Nationwide population-based study.
We investigated the Korean National Health Insurance Service-National Sample Cohort, a representative one million-sample of the Korean population, for patients diagnosed with blepharitis according to the Korean Classification of Diseases.
Annual and overall incidence and prevalence of blepharitis during the study period (2004-2013) were estimated after excluding chronic blepharitis patients, diagnosed during 2002-2003. Sociodemographic factors and comorbidities associated with blepharitis were evaluated using Cox proportional hazard regression.
The first occurrence of blepharitis.
A total of 1 116 363 individuals over 9 698 118 person-years were evaluated (mean follow up: 8.7 years) from 2004 to 2013. The overall incidence was 1.1 (95% confidence interval, 1.1-1.1) per 100 person-years. The incidence increased with time (0.9 vs. 1.3 per 100 person-years, in 2004 and 2013, respectively) and was higher in female patients (1.3 vs. 0.9 per 100 person-years, respectively). The overall prevalence was 8.1% (95% confidence interval: 8.0-8.1) among subjects aged 40 years or older. Chalazion, gastritis, Sjögren's syndrome, pterygium, rosacea, prostatic hypertrophy, atopy, irritable bowel disease and peptic ulcer were associated with an increased incidence of blepharitis in the multivariable Cox model.
We found that blepharitis was a relatively common disease and is associated with various ocular and systemic conditions.
睑缘炎是最常见的病症之一。然而，尚无研究通过评估大量基于人群的样本对其流行病学进行评估。
评估韩国临床诊断睑缘炎的发病率和患病率。
全国性基于人群的研究。
我们根据韩国疾病分类法，对韩国国民健康保险服务全国样本队列（韩国人口的代表性百万样本）中诊断为睑缘炎的患者进行了调查。
在排除2002 - 2003年期间诊断的慢性睑缘炎患者后，估计研究期间（2004 - 2013年）睑缘炎的年度发病率和总体发病率及患病率。使用Cox比例风险回归评估与睑缘炎相关的社会人口学因素和合并症。
睑缘炎的首次发生情况。
2004年至2013年期间，对9698118人年中的1116363人进行了评估（平均随访时间：8.7年）。总体发病率为每100人年1.1例（95%置信区间，1.1 - 1.1）。发病率随时间增加（2004年和2013年分别为每100人年0.9例和1.3例），女性患者发病率更高（分别为每100人年1.3例和0.9例）。40岁及以上受试者的总体患病率为8.1%（95%置信区间：8.0 - 8.1）。在多变量Cox模型中，睑板腺囊肿、胃炎、干燥综合征、翼状胬肉、酒渣鼻、前列腺肥大、特应性、肠易激综合征和消化性溃疡与睑缘炎发病率增加相关。
我们发现睑缘炎是一种相对常见的疾病，且与多种眼部和全身疾病相关。
