Rim Tyler Hyungtaek, Kim Sung Soo, Ham Don-Il, Yu Seung-Young, Chung Eun Jee, Lee Sung Chul
Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, South Korea.
Yonsei Healthcare Big Data Based Knowledge Integration System Research Center, Yonsei University College of Medicine, Seoul, South Korea.
Br J Ophthalmol. 2018 Jan;102(1):79-83. doi: 10.1136/bjophthalmol-2016-309829. Epub 2017 Jun 8.
To evaluate the incidence and prevalence of uveitis and associated risk factors in South Korea.
For this retrospective national cohort study, approximately 1 000 000 Korean residents were randomly selected from the Korean National Health Insurance Service database. Uveitis was defined according to the Korean Classification of Diseases. The uveitis incidence and prevalence were calculated. Sociodemographic factors and comorbidities associated with uveitis were evaluated via Cox proportional regression models.
A total of 1 094 440 subjects were evaluated over 7 051 346 person-years (mean follow-up: 6.44 years). Overall, 7447 newly developed uveitis cases were identified during the period of 2007-2013; the average incidence of uveitis was 10.6 per 10 000 person-years (95% CI 10.3 to 10.8). The average incidences of anterior and non-anterior uveitis were 9.0 and 1.5 per 10 000 person-years, respectively. The prevalence rates of uveitis, anterior uveitis and non-anterior uveitis were 17.3, 15.0 and 2.3 per 10 000 persons, respectively, during the period of 2007-2013. Increasing age, male sex, residing in a relatively rural area and high income were associated with uveitis, along with Behçet's disease, juvenile idiopathic arthritis, ankylosing spondylitis, systemic lupus erythematous, ulcerative colitis and tuberculosis.
The overall incidence of uveitis in Korea was similar to those reported in Taiwan and the USA. Despite a potentially inaccurate disease definition, claims data may be useful for monitoring the substantial uveitis burden in South Korea.
评估韩国葡萄膜炎的发病率、患病率及相关危险因素。
在这项回顾性全国队列研究中，从韩国国民健康保险服务数据库中随机选取约100万韩国居民。葡萄膜炎根据韩国疾病分类进行定义。计算葡萄膜炎的发病率和患病率。通过Cox比例回归模型评估与葡萄膜炎相关的社会人口统计学因素和合并症。
在7051346人年期间共评估了1094440名受试者（平均随访时间：6.44年）。总体而言，在2007 - 2013年期间共确定了7447例新发生的葡萄膜炎病例；葡萄膜炎的平均发病率为每10000人年10.6例（95%可信区间10.3至10.8）。前葡萄膜炎和非前葡萄膜炎的平均发病率分别为每10000人年9.0例和1.5例。在2007 - 2013年期间，葡萄膜炎、前葡萄膜炎和非前葡萄膜炎的患病率分别为每10000人17.3例、15.0例和2.3例。年龄增加、男性、居住在相对农村地区和高收入与葡萄膜炎相关，同时还与白塞病、幼年特发性关节炎、强直性脊柱炎、系统性红斑狼疮、溃疡性结肠炎和结核病有关。
韩国葡萄膜炎的总体发病率与台湾和美国报告的相似。尽管疾病定义可能不准确，但索赔数据可能有助于监测韩国葡萄膜炎的沉重负担。
