Deepashree S, Shivanandappa T, Ramesh S R
Unit on Evolution and Genetics, Department of Studies in Zoology, University of Mysore, Manasagangotri, MYSURU- 570006, Karnataka, India.
Department of Studies in Zoology, University of Mysore, Manasagangotri, Mysuru-570 006, Karnataka, India.
Curr Aging Sci. 2017;10(3):224-238. doi: 10.2174/1874609810666170209111350.
Aging or senescence is a complex biological phenomenon. Artificially selected Drosophila for extended longevity is one of the experimental models used to understand the mechanisms involved in aging and to test various theories.
To examine the life history traits and biochemical defenses in relation to aging in an extended longevity phenotype of Drosophila melanogaster.
Life history traits viz., survivability, fecundity, development time, dry weight, wing size, lipid content, starvation, desiccation and cold resistances, locomotory ability, antioxidant enzyme activities and reactive oxygen species level between control and selected lines of D. melanogaster were investigated.
In our model of Drosophila, extended longevity is associated with no trade-off in fecundity and shows variable resistance to environmental stress such as starvation, cold and desiccation. Enhanced biochemical defense involving the antioxidant enzymes was positively correlated with longevity.
Extended longevity phenotypes of Drosophila represent genomic plasticity associated with variable life history traits attributed to the genetic background of the progenitor population and the environment of selection. Oxidative stress resistance seems to be a significant factor in longevity.
衰老或老化是一种复杂的生物学现象。人工选择寿命延长的果蝇是用于理解衰老相关机制和检验各种理论的实验模型之一。
研究黑腹果蝇寿命延长表型中与衰老相关的生活史特征和生化防御机制。
研究了黑腹果蝇对照品系和选择品系之间的生活史特征，即存活率、繁殖力、发育时间、干重、翅大小、脂质含量、饥饿、干燥和耐寒能力、运动能力、抗氧化酶活性和活性氧水平。
在我们的果蝇模型中，寿命延长与繁殖力无权衡关系，且对饥饿、寒冷和干燥等环境应激具有不同的抗性。涉及抗氧化酶的增强生化防御与寿命呈正相关。
果蝇的寿命延长表型代表了基因组可塑性，与归因于祖代群体遗传背景和选择环境的可变生活史特征相关。抗氧化应激似乎是长寿的一个重要因素。
