Yu Weijiang, Jiang Guohua, Liu Depeng, Li Lei, Tong Zaizai, Yao Juming, Kong Xiangdong
Department of Materials Engineering, Zhejiang Sci Tech University, Hangzhou 310018, China.
Department of Materials Engineering, Zhejiang Sci Tech University, Hangzhou 310018, China; National Engineering Laboratory for Textile Fiber Materials and Processing Technology (Zhejiang), Hangzhou 310018, China; Key Laboratory of Advanced Textile Materials and Manufacturing Technology (ATMT), Ministry of Education, Hangzhou 310018, China.
Mater Sci Eng C Mater Biol Appl. 2017 Apr 1;73:425-428. doi: 10.1016/j.msec.2016.12.111. Epub 2016 Dec 23.
The organic-inorganic bioceramic composite microneedles (MNs) were prepared from hydroxyapatite (Hap) and gelatin (Gel) via a template method. The resultant hydroxyapatite and gelatin composite MNs exhibited low cytotoxicity and excellent mechanical properties. After transdermal administration to the diabetic rats, the insulin could be released from bioceramic composite MNs. An obvious and effective hypoglycemic effect could be obtained compared with that of subcutaneous injection route. This work suggests that bioceramic composite MNs containing of insulin have a potential application in diabetes treatment via transdermal ingestion.
通过模板法由羟基磷灰石（Hap）和明胶（Gel）制备了有机-无机生物陶瓷复合微针（MNs）。所得的羟基磷灰石和明胶复合微针表现出低细胞毒性和优异的机械性能。对糖尿病大鼠进行经皮给药后，胰岛素可从生物陶瓷复合微针中释放出来。与皮下注射途径相比，可获得明显且有效的降血糖效果。这项工作表明，含胰岛素的生物陶瓷复合微针在经皮摄入治疗糖尿病方面具有潜在应用。
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