Cao Wenbin, Xing Huanchun, Guo Shuai, Wang Lin, Sui Xin, Huang Lijuan, Luo Yuan, Yang Jun, Wang Yongan
State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institutes of Pharmacology and Toxicology, Beijing 100850, China.
Tianjin University of Science and Technology, Tianjin 300222, China.
Biomater Res. 2024 Sep 16;28:0083. doi: 10.34133/bmr.0083. eCollection 2024.
Skin damage caused by chemical corrosion is currently one of the common skin diseases and poisoning symptoms, with nitrogen mustard compounds causing the most persistent and severe damage. These chemicals penetrate the top layer of the skin, enter the dermis, and cause DNA damage, oxidative stress, and inflammation. However, to date, no effective drug treatment has been found. Even the potential antidotes could not effectively penetrate the top layer of the skin to exert their effects due to the skin barrier. To address this problem, an innovative transdermal drug delivery strategy based on aspirin microneedles was proposed. The classic medicine aspirin was first discovered not only to reduce inflammation and oxidative stress but also to promote DNA repair and reduce DNA damage. The aspirin microneedles directly delivered the drug to the damaged area, released aspirin through the skin barrier, and exhibited good biocompatibility. These findings indicate that aspirin microneedles have great potential for promoting wound healing and broad application prospects.
化学腐蚀引起的皮肤损伤是目前常见的皮肤疾病和中毒症状之一，其中氮芥化合物造成的损伤最为持久和严重。这些化学物质穿透皮肤表层，进入真皮层，导致DNA损伤、氧化应激和炎症。然而，迄今为止，尚未找到有效的药物治疗方法。由于皮肤屏障的存在，即使是潜在的解毒剂也无法有效穿透皮肤表层发挥作用。为了解决这一问题，提出了一种基于阿司匹林微针的创新透皮给药策略。经典药物阿司匹林最初被发现不仅能减轻炎症和氧化应激，还能促进DNA修复并减少DNA损伤。阿司匹林微针将药物直接输送到受损区域，通过皮肤屏障释放阿司匹林，并表现出良好的生物相容性。这些发现表明，阿司匹林微针在促进伤口愈合方面具有巨大潜力和广阔的应用前景。
