Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, SE 106 91 Stockholm, Sweden.
Unit of Chemical Ecology, Department of Plant Protection Biology, SLU, SE 230 53 Alnarp, Sweden.
Science. 2017 Mar 10;355(6329):1076-1080. doi: 10.1126/science.aah4563. Epub 2017 Feb 9.
Malaria infection renders humans more attractive to sensu lato mosquitoes than uninfected people. The mechanisms remain unknown. We found that an isoprenoid precursor produced by , ()-4-hydroxy-3-methyl-but-2-enyl pyrophosphate (HMBPP), affects s.l. blood meal seeking and feeding behaviors as well as susceptibility to infection. HMBPP acts indirectly by triggering human red blood cells to increase the release of CO, aldehydes, and monoterpenes, which together enhance vector attraction and stimulate vector feeding. When offered in a blood meal, HMBPP modulates neural, antimalarial, and oogenic gene transcription without affecting mosquito survival or fecundity; in a -infected blood meal, sporogony is increased.
疟原虫感染会使人类比未感染者对广义蚊子更具吸引力。其机制尚不清楚。我们发现，由 ()-4-羟基-3-甲基-2-丁烯基焦磷酸（HMBPP）产生的异戊二烯前体影响广义按蚊的血餐寻求和摄食行为以及对感染的易感性。HMBPP 通过间接作用于人类红细胞，使其增加 CO、醛和单萜的释放，从而共同增强媒介吸引力并刺激媒介摄食。当在血餐中提供时，HMBPP 调节神经、抗疟和产卵基因转录，而不影响蚊子的生存或繁殖力；在感染的血餐中，孢子生殖增加。
