Division of Cardiology, Department of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Division of Cardiovascular Diseases, University of Cincinnati, 231 Albert Sabin Way, Mail location MLB 052, Cincinnati, OH, 45267-0542, USA.
J Nucl Cardiol. 2018 Aug;25(4):1110-1113. doi: 10.1007/s12350-017-0809-z. Epub 2017 Feb 9.
Diastolic heart failure accounts for half of the heart failure population and its pathophysiology remains an area of active research. The renin angiotensin and aldosterone axis has been the focus of clinical trials to treat patients with heart failure with preserved ejection fraction, however with limited yield in terms of clinical success. Sympathetic activity has been considered a plausible cause for the molecular changes that lead to diastolic dysfunction. Based on this understanding the study by Gimelli et al uses MIBG to evaluate for association between diastolic dysfunction and sympathetic denervation. The results of this study set the stage for a follow up study for evaluation of sympathetic denervation in isolated diastolic dysfunction.
舒张性心力衰竭占心力衰竭患者的一半，其病理生理学仍是一个活跃的研究领域。肾素-血管紧张素-醛固酮轴一直是治疗射血分数保留心力衰竭患者的临床试验的重点，但在临床成功方面收效有限。交感神经活动被认为是导致舒张功能障碍的分子变化的一个合理原因。基于这一认识，Gimelli 等人的研究使用 MIBG 来评估舒张功能障碍与交感神经去神经支配之间的关系。这项研究的结果为后续研究孤立性舒张性心力衰竭患者的交感神经去神经支配奠定了基础。
