与白蛋白结合的色氨酸发生移位，是如何导致血浆中游离色氨酸浓度持续升高以及大脑中5-羟色胺合成增加的？
How does displacement of albumin-bound tryptophan cause sustained increases in the free tryptophan concentration in plasma and 5-hydroxytryptamine synthesis in brain?
作者信息
Salter M, Knowles R G, Pogson C I
机构信息
Biochemical Sciences, Wellcome Research Laboratory, Beckenham, Kent, U.K.
出版信息
Biochem J. 1989 Aug 15;262(1):365-8. doi: 10.1042/bj2620365.
Abstract
Models of tryptophan catabolism and binding to serum albumin are presented to explain the observed effect of displacement of tryptophan from albumin on the concentrations of free and bound tryptophan and on the rate of 5-hydroxytryptamine (5-HT) synthesis from tryptophan in the brain. A rapid rate of dissociation of tryptophan from albumin (compared to the transit time of tryptophan through the liver) and a large fractional extraction of the free pool of tryptophan during passage through the liver are shown to be necessary factors in determining the effects observed. Because of the low fractional extraction of free tryptophan in the brain, the synthesis of 5-HT will be dependent only upon the free pool of tryptophan. Dissociation of tryptophan from albumin only causes a sustained increase in 5-HT synthesis in the brain because of the effect that this dissociation has on hepatic tryptophan catabolism and thereby on the free pool of tryptophan.
摘要
本文提出了色氨酸分解代谢及与血清白蛋白结合的模型，以解释所观察到的色氨酸从白蛋白上解离后，对游离色氨酸和结合色氨酸浓度以及大脑中色氨酸合成5-羟色胺（5-HT）速率的影响。色氨酸从白蛋白上的快速解离（与色氨酸通过肝脏的转运时间相比）以及色氨酸游离池在通过肝脏过程中的大量分数提取，被证明是决定所观察到的效应的必要因素。由于大脑中游离色氨酸的分数提取率较低，5-HT的合成将仅取决于色氨酸的游离池。色氨酸从白蛋白上的解离仅会导致大脑中5-HT合成的持续增加，这是因为这种解离对肝脏色氨酸分解代谢以及由此对色氨酸游离池产生的影响。
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