纳洛酮对吗啡对大鼠肝脏和脑色氨酸代谢的慢性影响的快速逆转作用。
Rapid reversal by naloxone of the chronic effects of morphine on rat liver and brain tryptophan metabolism.
作者信息
Badawy A A, Evans M
出版信息
Br J Pharmacol. 1981 Nov;74(3):511-3. doi: 10.1111/j.1476-5381.1981.tb10457.x.
Abstract
The chronic morphine-induced inhibition of rat liver tryptophan pyrrolase activity and the resultant increases in tryptophan availability to the brain and brain 5-hydroxytryptamine (5-HT) synthesis are reversed within 10 min after naloxone administration. The possible involvement of hepatic tryptophan metabolism in morphine dependence is briefly discussed.
摘要
慢性吗啡诱导的大鼠肝脏色氨酸吡咯酶活性抑制以及由此导致的大脑色氨酸可用性增加和大脑5-羟色胺（5-HT）合成增加，在给予纳洛酮后10分钟内逆转。简要讨论了肝脏色氨酸代谢在吗啡依赖中的可能作用。
相似文献
1
Rapid reversal by naloxone of the chronic effects of morphine on rat liver and brain tryptophan metabolism.纳洛酮对吗啡对大鼠肝脏和脑色氨酸代谢的慢性影响的快速逆转作用。
Br J Pharmacol. 1981 Nov;74(3):511-3. doi: 10.1111/j.1476-5381.1981.tb10457.x.
2
Reversal by naloxone of the effects of chronic administration of drugs of dependence on rat liver and brain tryptophan metabolism.纳洛酮对长期给予依赖性药物对大鼠肝脏和脑色氨酸代谢影响的逆转作用。
Br J Pharmacol. 1981 Oct;74(2):489-94. doi: 10.1111/j.1476-5381.1981.tb09995.x.
3
The role of liver tryptophan pyrrolase in the opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on rat brain tryptophan metabolism.肝脏色氨酸吡咯酶在长期给药及随后停用依赖性药物对大鼠脑色氨酸代谢产生的相反作用中的作用。
Biochem J. 1981 Apr 15;196(1):161-70. doi: 10.1042/bj1960161.
4
Does naloxone always act as an opiate antagonist?纳洛酮是否总是起阿片类拮抗剂的作用？
Life Sci. 1983;33 Suppl 1:739-42. doi: 10.1016/0024-3205(83)90608-2.
5
Effect of acute administration of morphine on newly synthesized 5-hydroxytryptamine in spinal cord of the rat.急性给予吗啡对大鼠脊髓中新合成的5-羟色胺的影响。
Brain Res. 1980 Oct 20;199(2):415-24. doi: 10.1016/0006-8993(80)90698-8.
6
Inhibition of rat brain tryptophan metabolism by ethanol withdrawal and possible involvement of the enhanced liver tryptophan pyrrolase activity.乙醇戒断对大鼠脑色氨酸代谢的抑制作用以及肝脏色氨酸吡咯酶活性增强可能与之有关。
Biochem J. 1980 Nov 15;192(2):449-55. doi: 10.1042/bj1920449.
7
Enhancement of rat brain tryptophan metabolism by chronic ethanol administration and possible involvement of decreased liver tryptophan pyrrolase activity.长期给予乙醇对大鼠脑色氨酸代谢的增强作用以及肝脏色氨酸吡咯酶活性降低可能与之有关。
Biochem J. 1979 Mar 15;178(3):575-80. doi: 10.1042/bj1780575.
8
Effects of the haem precursor 5-aminolaevulinate on tryptophan metabolism and disposition in the rat.血红素前体5-氨基乙酰丙酸对大鼠色氨酸代谢及分布的影响。
Biochem J. 1987 Nov 15;248(1):293-5. doi: 10.1042/bj2480293.
9
Elevated brain tryptophan and enhanced 5-hydroxytryptamine turnover in acute hepatic heme deficiency: clinical implications.急性肝性血红素缺乏时脑色氨酸升高及5-羟色胺代谢增强：临床意义
J Pharmacol Exp Ther. 1985 Feb;232(2):337-45.
10
Increase in 5-HT synthesis in the dorsal part of the spinal cord, induced by a nociceptive stimulus: blockade by morphine.伤害性刺激诱导脊髓背侧5-羟色胺合成增加：吗啡的阻断作用
Brain Res. 1984 Apr 16;297(2):247-64. doi: 10.1016/0006-8993(84)90566-3.
本文引用的文献
1
Reversal by naloxone of the effects of chronic administration of drugs of dependence on rat liver and brain tryptophan metabolism.纳洛酮对长期给予依赖性药物对大鼠肝脏和脑色氨酸代谢影响的逆转作用。
Br J Pharmacol. 1981 Oct;74(2):489-94. doi: 10.1111/j.1476-5381.1981.tb09995.x.
2
The role of liver tryptophan pyrrolase in the opposite effects of chronic administration and subsequent withdrawal of drugs of dependence on rat brain tryptophan metabolism.肝脏色氨酸吡咯酶在长期给药及随后停用依赖性药物对大鼠脑色氨酸代谢产生的相反作用中的作用。
Biochem J. 1981 Apr 15;196(1):161-70. doi: 10.1042/bj1960161.
3
Role of serotonin in morphine effects.血清素在吗啡作用中的角色。
Fed Proc. 1972 Jan-Feb;31(1):113-20.
4
Brain 5-hydroxytryptamine and cyclic AMP in morphine tolerance and dependence.脑内5-羟色胺与环磷酸腺苷在吗啡耐受性和依赖性中的作用
Adv Biochem Psychopharmacol. 1974;10:219-31.
5
The effects of ethanol on tryptophan pyrrolase activity and their comparison with those of phenobarbitone and morphine.乙醇对色氨酸吡咯酶活性的影响及其与苯巴比妥和吗啡影响的比较。
Adv Exp Med Biol. 1975;59:229-51. doi: 10.1007/978-1-4757-0632-1_15.
6
7
Enhancement of rat brain tryptophan metabolism by chronic ethanol administration and possible involvement of decreased liver tryptophan pyrrolase activity.长期给予乙醇对大鼠脑色氨酸代谢的增强作用以及肝脏色氨酸吡咯酶活性降低可能与之有关。
Biochem J. 1979 Mar 15;178(3):575-80. doi: 10.1042/bj1780575.
8
The effects of acute and chronic nicotine hydrogen (+)-tartrate administration and subsequent withdrawal on rat liver tryptophan pyrrolase activity and their comparison with those of morphine, phenobarbitone and ethanol.急性和慢性给予尼古丁酒石酸氢（+）盐及其随后撤药对大鼠肝脏色氨酸吡咯酶活性的影响，以及与吗啡、苯巴比妥和乙醇影响的比较。
Biochem J. 1975 Jun;148(3):425-32. doi: 10.1042/bj1480425.
Zotero 插件