Semsei I, Rao G, Richardson A
Department of Chemistry, Illinois State University, Normal 61761.
Biochem Biophys Res Commun. 1989 Oct 31;164(2):620-5. doi: 10.1016/0006-291x(89)91505-2.
The activities of superoxide dismutase (Cu/Zn) and catalase were observed to decrease significantly between 6 and 29 months of age in rat liver. The decrease in superoxide dismutase and catalase activity was paralleled by a decrease in the levels of the mRNA species coding for these enzymes and the nuclear transcription of the superoxide dismutase and catalase genes. Life-long dietary restriction was shown to increase the expression (i.e. activities, mRNA levels, and nuclear transcription) of superoxide dismutase and catalase in liver tissue from 18-month-old rats.
超氧化物歧化酶（铜/锌）和过氧化氢酶的活性在大鼠肝脏6至29月龄期间显著降低。超氧化物歧化酶和过氧化氢酶活性的降低伴随着编码这些酶的mRNA种类水平以及超氧化物歧化酶和过氧化氢酶基因的核转录的降低。终生饮食限制显示可增加18月龄大鼠肝脏组织中超氧化物歧化酶和过氧化氢酶的表达（即活性、mRNA水平和核转录）。
