Sogabe T, Matsumae M, Sato O, Miura I
Tokushima Institute, Otsuka Pharmaceutical Co., Japan.
Biochem Int. 1989 Sep;19(3):513-8.
Energy metabolism was studied by measurements of the activity and isozyme pattern of lactate dehydrogenase (LDH) in rats with kaolin-induced hydrocephalus at 1, 2, 4, and 6 weeks after the induction, as well as in normal, control rats. The total LDH activity in hydrocephalic rats was 1.5 times that in controls throughout the examination period. The main LDH isozyme in hydrocephalic rats was LDH 5(M4) at 2 weeks, but the isozyme pattern was the same as in controls at 4 and 6 weeks. These results suggest that the ratio of anaerobic to aerobic glycolysis increases in the acute stage of hydrocephalus and gradually lowers to become similar to that in controls with time.
通过测量高岭土诱导脑积水大鼠在诱导后1、2、4和6周以及正常对照大鼠中乳酸脱氢酶（LDH）的活性和同工酶模式，研究能量代谢。在整个检查期间，脑积水大鼠的总LDH活性是对照组的1.5倍。脑积水大鼠的主要LDH同工酶在2周时为LDH 5（M4），但在4周和6周时同工酶模式与对照组相同。这些结果表明，在脑积水急性期，无氧糖酵解与有氧糖酵解的比例增加，随着时间的推移逐渐降低，变得与对照组相似。
