Department of Electrophysiology, Sir Run Run Shaw Hospital, Medical College, Zhejiang University, Hangzhou, China.
Institute of Anatomy and Cell Biology, Medical College, Zhejiang University, Hangzhou, China.
Sci Rep. 2017 Feb 10;7:41837. doi: 10.1038/srep41837.
Placental derived mesenchymal stem cells (PMSCs) have been suggested as a possible source of cells to treat multiple sclerosis (MS) due to their immunomodulatory functions, lack of ethical concerns, and potential to differentiate into neurons and oligodendrocytes. To investigate whether PMSCs share similar characteristics with embryonic mesenchymal stem cells (EMSCs), and if transplanted PMSCs have the ability to integrate and replace degenerated neural cells, we transplanted rat PMSCs and EMSCs into the central nervous system (CNS) of Lewis rats with experimental autoimmune encephalomyelitis (EAE), an animal model of MS. Our findings demonstrated that transplanted PMSCs, similar to EMSCs, were effective in decreasing infiltrating inflammatory cells, preserving axons, and ameliorating demyelination, thereby improving the neurological functions of animals. Moreover, both PMSCs and EMSCs had the ability to migrate into inflamed tissues and express neural-glial lineage markers. These findings suggest that PMSCs may replace EMSCs as a source of cells in MS stem cell therapy.
胎盘来源间充质干细胞（PMSCs）因其免疫调节功能、无伦理问题以及向神经元和少突胶质细胞分化的潜能，被认为是治疗多发性硬化症（MS）的一种潜在细胞来源。为了研究 PMSCs 是否与胚胎间充质干细胞（EMSCs）具有相似的特征，以及移植的 PMSCs 是否具有整合和替代退化神经细胞的能力，我们将大鼠 PMSCs 和 EMSCs 移植到实验性自身免疫性脑脊髓炎（EAE）大鼠的中枢神经系统（CNS）中，EAE 是 MS 的动物模型。我们的研究结果表明，与 EMSCs 类似，移植的 PMSCs 可有效减少浸润的炎症细胞，保护轴突，并改善脱髓鞘，从而改善动物的神经功能。此外，PMSCs 和 EMSCs 均具有迁移到炎症组织并表达神经胶质谱系标志物的能力。这些发现表明，PMSCs 可能替代 EMSCs 成为 MS 干细胞治疗的细胞来源。
