Mariga Abigail, Mitre Mariela, Chao Moses V
Department of Cell Biology, New York University School of Medicine, New York, NY, 10016, United States; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, 10016, United States.
Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY, 10016, United States; Skirball Institute for Biomolecular Medicine, New York University School of Medicine, New York, NY, 10016, United States.
Neurobiol Dis. 2017 Jan;97(Pt B):73-79. doi: 10.1016/j.nbd.2016.03.009. Epub 2016 Mar 22.
Growth factor withdrawal has been studied across different species and has been shown to have dramatic consequences on cell survival. In the nervous system, withdrawal of nerve growth factor (NGF) from sympathetic and sensory neurons results in substantial neuronal cell death, signifying a requirement for NGF for the survival of neurons in the peripheral nervous system (PNS). In contrast to the PNS, withdrawal of central nervous system (CNS) enriched brain-derived neurotrophic factor (BDNF) has little effect on cell survival but is indispensible for synaptic plasticity. Given that most early events in neuropsychiatric disorders are marked by a loss of synapses, lack of BDNF may thus be an important part of a cascade of events that leads to neuronal degeneration. Here we review reports on the effects of BDNF withdrawal on CNS neurons and discuss the relevance of the loss in disease.
生长因子撤除已在不同物种中进行了研究，并已证明对细胞存活具有显著影响。在神经系统中，从交感神经元和感觉神经元中撤除神经生长因子（NGF）会导致大量神经元细胞死亡，这表明外周神经系统（PNS）中的神经元存活需要NGF。与PNS相反，撤除中枢神经系统（CNS）富集的脑源性神经营养因子（BDNF）对细胞存活影响很小，但对突触可塑性却是必不可少的。鉴于神经精神疾病中的大多数早期事件都以突触丧失为特征，因此BDNF的缺乏可能是导致神经元变性的一系列事件的重要组成部分。在此，我们综述了关于BDNF撤除对CNS神经元影响的报告，并讨论了其缺失在疾病中的相关性。
