Price Adam, Gibas Cynthia
Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, NC, 28223-0001, USA.
Bioinformatics. 2017 Jun 15;33(12):1876-1878. doi: 10.1093/bioinformatics/btx091. Epub 2017 Feb 10.
Simulome provides a powerful and easy to use tool for creating prokaryotic pseudo-genomes. It provides options that can be used in combination to create mutated variants of the simulated genome, which allows for controlled testing of specific genomic conditions. Simulome can be used in combination with real reads generated from next-generation sequencing platforms, or with simulated reads.
Simulome is available for download at https://github.com/price0416/Simulome and is free for use under the MIT license.
Simulome提供了一个功能强大且易于使用的工具来创建原核生物伪基因组。它提供了多种可组合使用的选项，用于创建模拟基因组的突变变体，从而能够对特定基因组条件进行可控测试。Simulome可与从下一代测序平台生成的真实 reads 结合使用，也可与模拟 reads 结合使用。
可在https://github.com/price0416/Simulome上下载Simulome，根据麻省理工学院许可免费使用。
