Department of Pharmacy.
Research Centre.
J Pediatric Infect Dis Soc. 2017 Nov 24;6(4):389-392. doi: 10.1093/jpids/piw087.
Plasma posaconazole exposure was assessed in 13 children who underwent a hematopoietic stem cell transplant. The median dosage was 12.5 mg/kg per day, divided into 3 doses. Of these 13 patients, 46.2% (6) and 30.8% (4) achieved concentrations higher than 0.7 and 1.25 mg/L, respectively. In children at high risk, a higher dosage might be needed to achieve target concentrations.
对 13 名接受造血干细胞移植的儿童进行了泊沙康唑血药浓度监测。中位剂量为 12.5mg/kg/天，分 3 次给药。在这 13 名患者中，分别有 46.2%（6 名）和 30.8%（4 名）达到了 0.7mg/L 以上和 1.25mg/L 以上的浓度。对于高危患儿，可能需要更高的剂量来达到目标浓度。
