FEN1的相互作用蛋白及其在抗癌治疗发展中的作用。
Interacting partners of FEN1 and its role in the development of anticancer therapeutics.
作者信息
Kathera Chandrasekhar, Zhang Jing, Janardhan Avilala, Sun Hongfang, Ali Wajid, Zhou Xiaolong, He Lingfeng, Guo Zhigang
机构信息
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China.
The Laboratory of Animal Genetics, Breeding, and Reproduction, College of Animal Science and Technology, Zhejiang Agriculture and Forestry University, Hangzhou, China.
出版信息
Oncotarget. 2017 Apr 18;8(16):27593-27602. doi: 10.18632/oncotarget.15176.
Protein-protein interaction (PPI) plays a key role in cellular communication, Protein-protein interaction connected with each other with hubs and nods involved in signaling pathways. These interactions used to develop network based biomarkers for early diagnosis of cancer. FEN1(Flap endonuclease 1) is a central component in cellular metabolism, over expression and decrease of FEN1 levels may cause cancer, these regulation changes of Flap endonuclease 1reported in many cancer cells, to consider this data may needs to develop a network based biomarker. The current review focused on types of PPI, based on nature, detection methods and its role in cancer. Interacting partners of Flap endonuclease 1 role in DNA replication repair and development of anticancer therapeutics based on Protein-protein interaction data.
蛋白质-蛋白质相互作用（PPI）在细胞通讯中起关键作用，蛋白质-蛋白质相互作用通过参与信号通路的枢纽和节点相互连接。这些相互作用过去常被用于开发基于网络的生物标志物以进行癌症的早期诊断。FEN1（翼状内切核酸酶1）是细胞代谢的核心成分，FEN1水平的过度表达和降低可能会导致癌症，许多癌细胞中都报道了翼状内切核酸酶1的这些调控变化，考虑到这些数据可能需要开发一种基于网络的生物标志物。当前的综述聚焦于PPI的类型、基于性质的检测方法及其在癌症中的作用。翼状内切核酸酶1的相互作用伙伴在DNA复制修复中的作用以及基于蛋白质-蛋白质相互作用数据的抗癌治疗药物的开发。
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