γ-羟基丁酸对大鼠乙醇戒断综合征的抑制作用。
Suppression by gamma-hydroxybutyric acid of ethanol withdrawal syndrome in rats.
作者信息
Fadda F, Colombo G, Mosca E, Gessa G L
机构信息
Institute of Physiology, University of Cagliari, Italy.
出版信息
Alcohol Alcohol. 1989;24(5):447-51.
The ability of gamma-hydroxybutyric acid to suppress ethanol withdrawal syndrome was tested in male rats rendered physically dependent on ethanol by several intragastric administrations of ethanol (9-15 g/kg daily for 7 days). Gamma-hydroxybutyrate (0.25, 0.50 and 1.00 g/kg i.p.), administered 8 hr after the last ethanol dose, produced a dose-dependent inhibition of withdrawal signs such as tremors and audiogenically-induced seizures; the highest dose tested suppressed all ethanol withdrawal symptoms.
通过多次胃内给予乙醇（每天9 - 15克/千克，持续7天）使雄性大鼠对乙醇产生身体依赖，以此来测试γ-羟基丁酸抑制乙醇戒断综合征的能力。在最后一次给予乙醇8小时后腹腔注射γ-羟基丁酸盐（0.25、0.50和1.00克/千克），可产生剂量依赖性地抑制戒断症状，如震颤和听源性惊厥；所测试的最高剂量可抑制所有乙醇戒断症状。
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