2-氯-N6-环戊基腺苷（CCPA），一种腺苷A1受体激动剂，可抑制大鼠的乙醇戒断综合征。
2-Chloro-N6-cyclopentyladenosine (CCPA), an adenosine A1 receptor agonist, suppresses ethanol withdrawal syndrome in rats.
作者信息
Concas A, Cuccheddu T, Floris S, Mascia M P, Biggio G
机构信息
Department of Experimental Biology, University of Cagliari, Italy.
出版信息
Alcohol Alcohol. 1994 May;29(3):261-4.
The ability of 2-chloro-N6-cyclopentyladenosine (CCPA) to suppress ethanol withdrawal syndrome was tested in male rats rendered physically dependent on ethanol by intragastric administrations of ethanol (12-18 g/kg daily for 6 days). CCPA administered 24 hr after the last ethanol dose produced a dose-dependent inhibition of withdrawal signs such as tremors and audiogenically induced seizures, an effect prevented by the A1 receptor antagonist 8-cyclopentyl-1,3-dipropylxanthine (DPCPX).
通过对雄性大鼠进行胃内给予乙醇（每天12 - 18克/千克，持续6天）使其对乙醇产生身体依赖性，以此来测试2 - 氯 - N6 - 环戊基腺苷（CCPA）抑制乙醇戒断综合征的能力。在最后一剂乙醇给药24小时后给予CCPA，可产生剂量依赖性地抑制戒断症状，如震颤和听源性惊厥，A1受体拮抗剂8 - 环戊基 - 1,3 - 二丙基黄嘌呤（DPCPX）可阻止这种效应。
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