Jørgensen Anders N, Aagaard Per, Nielsen Jakob L, Christiansen Mette, Hvid Lars G, Frandsen Ulrik, Diederichsen Louise P
Department of Rheumatology, Odense University Hospital, Odense, Denmark.
Department of Sports Science and Clinical Biomechanics, SDU Muscle Research Cluster, University of Southern Denmark, Odense, Denmark.
Muscle Nerve. 2017 Dec;56(6):E50-E58. doi: 10.1002/mus.25603. Epub 2017 Apr 10.
In this study, self-reported physical function, functional capacity, and isolated muscle function were investigated in sporadic inclusion body myositis (sIBM) patients.
The 36-item Short Form (SF-36) Health Survey and 2-min walk test (2MWT), timed up & go test (TUG), and 30-s chair stand performance were evaluated. In addition, patients were tested for knee extensor muscle strength (isokinetic dynamometer) and leg extension power (Nottingham power rig).
TUG performance was the strongest predictor of self-reported physical function (r = 0.56, P < 0.05). Knee extension strength and between-limb strength asymmetry were the strongest multi-regression indicators of TUG performance (r = 0.51, P < 0.05). Strength asymmetry showed the strongest single-factor (negative) association with 2MWT performance (r = 0.49, P < 0.05).
TUG assessment appears to sensitively predict self-perceived physical function in sIBM patients. Notably, between-limb asymmetry in lower limb muscle strength had a substantial negative impact on motor tasks involving gait function. Muscle Nerve 56: E50-E58, 2017.
在本研究中，对散发性包涵体肌炎（sIBM）患者的自我报告身体功能、功能能力和孤立肌肉功能进行了调查。
评估了36项简短健康调查（SF - 36）、2分钟步行测试（2MWT）、计时起立行走测试（TUG）和30秒椅子站立表现。此外，还对患者进行了膝伸肌力量（等速测力计）和腿部伸展力量（诺丁汉力量测试装置）测试。
TUG表现是自我报告身体功能的最强预测指标（r = 0.56，P < 0.05）。膝伸肌力量和肢体间力量不对称是TUG表现的最强多元回归指标（r = 0.51，P < 0.05）。力量不对称与2MWT表现呈现最强的单因素（负）关联（r = 0.49，P < 0.05）。
TUG评估似乎能敏感地预测sIBM患者的自我感知身体功能。值得注意的是，下肢肌肉力量的肢体间不对称对涉及步态功能的运动任务有显著负面影响。《肌肉与神经》56：E50 - E58，2017年。
