NIHR Manchester Biomedical Research Centre, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, United Kingdom.
Muscle Nerve. 2020 Jul;62(1):76-82. doi: 10.1002/mus.26859. Epub 2020 Mar 13.
Objective information on longitudinal disease progression in inclusion body myositis (IBM) is lacking.
Longitudinal dynamometry and functional status data were collated from a cohort of IBM patients. Annual change was calculated by means of linear modeling. Trajectories of change in grip, knee extension, IBM Functional Rating Scale (IBM-FRS) and Neuromuscular Symptom Score (NSS) were identified by means of latent growth mixture modeling.
Data were collated from 75 IBM patients (348 person-years follow-up). Annual strength loss was greatest for pinch (-10%) and knee extension (-4%). Functional deterioration was greatest for males. Three distinct trajectory groups were identified. Rapid deterioration trajectory for grip strength was associated with younger diagnosis age. Rapid deterioration for knee extension strength was associated with older age of diagnosis.
This study has quantified strength change in IBM and identified distinct trajectory groups, which will aid prognostication and stratification for inclusion into future clinical trials.
包涵体肌炎（IBM）的纵向疾病进展缺乏客观信息。
从 IBM 患者队列中整理了纵向测力和功能状态数据。通过线性建模计算年度变化。通过潜在增长混合建模确定握力、膝关节伸展、IBM 功能评分（IBM-FRS）和神经肌肉症状评分（NSS）变化的轨迹。
共收集了 75 例 IBM 患者（348 人年随访）的数据。捏力（-10%）和膝关节伸展（-4%）的年度力量损失最大。男性功能恶化最严重。确定了三个不同的轨迹组。握力快速恶化轨迹与较年轻的诊断年龄相关。膝关节伸展力量的快速恶化与较晚的诊断年龄相关。
本研究量化了 IBM 的力量变化，并确定了不同的轨迹组，这将有助于预测和分层，以便纳入未来的临床试验。
