金黄色葡萄球菌感染中对中毒性休克综合征毒素-1（TSST-1）以及葡萄球菌肠毒素A、B和C的免疫反应。

Immune response to toxic-shock-syndrome toxin-1 (TSST-1) and to staphylococcal enterotoxins A, B and C in Staphylococcus aureus infections.

作者信息

Kunstmann G, Schröder E, Hasbach H, Pulverer G

机构信息

Institut für Medizinische Mikrobiologie und Hygiene, Universität zu Köln.

出版信息

Zentralbl Bakteriol. 1989 Oct;271(4):486-92. doi: 10.1016/s0934-8840(89)80109-4.

DOI:10.1016/s0934-8840(89)80109-4

PMID:2818798

Abstract

Isolates from 100 monomicrobial Staphylococcus aureus infections were tested for the production of TSST-1 and the enterotoxins A, B and C, which were found to be synthesized as a single toxin in 34 strains, or in combination of two or more toxins in 26. Acute phase sera and one or two further serum samples from 60 patients with toxigenic (either enterotoxins and/or TSST-1) S. aureus isolates were tested for humoral immune responses. Such immune responses occurred more frequently in septicemic than in localized staphylococcal infections, and more frequently against TSST-1 and the other enterotoxins than against enterotoxin A. Furthermore, the data suggest an immunological non-responsiveness to enterotoxin A in a considerable portion of the patients. The retrospective screening of the records of 15 selected patients for symptoms of Toxic-Shock-Syndrome revealed one case of probable TSS.

摘要

对从100例单微生物金黄色葡萄球菌感染中分离出的菌株进行检测，以确定其是否产生中毒性休克综合征毒素-1（TSST-1）以及肠毒素A、B和C。结果发现，34株菌株仅合成一种毒素，26株菌株合成两种或更多种毒素。对60例有毒性（产生肠毒素和/或TSST-1）金黄色葡萄球菌分离株的患者，检测其急性期血清以及一份或两份后续血清样本的体液免疫反应。此类免疫反应在败血症性葡萄球菌感染中比在局限性葡萄球菌感染中更常见，针对TSST-1和其他肠毒素的免疫反应比针对肠毒素A的更常见。此外，数据表明相当一部分患者对肠毒素A存在免疫无反应性。对15例选定患者的病历进行回顾性筛查，以查找中毒性休克综合征的症状，发现1例可能的中毒性休克综合征病例。