McGeachan Alexander J, Mcdermott Christopher J
Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK.
Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK
Pract Neurol. 2017 Apr;17(2):96-103. doi: 10.1136/practneurol-2016-001515. Epub 2017 Feb 10.
Sialorrhoea is a common and problematic symptom that arises from a range of neurological conditions associated with bulbar or facial muscle dysfunction. Drooling can significantly affect quality of life due to both physical complications such as oral chapping, and psychological complications such as embarrassment and social isolation. Thicker, tenacious oral and pharyngeal secretions may result from the drying management approach to sialorrhoea. The management of sialorrhoea in neurological diseases depends on the underlying pathology and severity of symptoms. Interventions include anticholinergic drugs, salivary gland-targeted radiotherapy, salivary gland botulinum toxin and surgical approaches. The management of thick secretions involves mainly conservative measures such as pineapple juice as a lytic agent, cough assist, saline nebulisers and suctioning or mucolytic drugs like carbocisteine. Despite a current lack of evidence and variable practice, management of sialorrhoea should form a part of the multidisciplinary approach needed for long-term neurological conditions.
流涎是一种常见且棘手的症状,由一系列与延髓或面部肌肉功能障碍相关的神经系统疾病引起。由于诸如口角干裂等身体并发症以及诸如尴尬和社交孤立等心理并发症,流口水会显著影响生活质量。对流涎采用的干燥管理方法可能会导致口腔和咽部分泌物变稠、黏稠。神经系统疾病中流涎的管理取决于潜在的病理状况和症状的严重程度。干预措施包括抗胆碱能药物、针对唾液腺的放射治疗、唾液腺肉毒杆菌毒素和手术方法。浓稠分泌物的管理主要涉及保守措施,如将菠萝汁用作溶解剂、咳嗽辅助、盐水雾化器以及抽吸,或使用如羧甲司坦等黏液溶解药物。尽管目前缺乏证据且实践存在差异,但流涎的管理应成为长期神经系统疾病所需多学科方法的一部分。