可能影响多形性低度恶性腺癌生长的因素。
Factors that may influence polymorphous low-grade adenocarcinoma growth.
作者信息
Soares Andresa Borges, Martinez Elizabeth Ferreira, Ribeiro Patricia Fernandes Avila, Barreto Icleia Siqueira, Aguiar Maria Cássia, Furuse Cristiane, Sperandio Marcelo, Montalli Victor Angelo, de Araújo Ney Soares, de Araújo Vera Cavalcanti
机构信息
Department of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
Department of Oral Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
出版信息
Virchows Arch. 2017 Apr;470(4):437-443. doi: 10.1007/s00428-017-2085-3. Epub 2017 Feb 10.
There is mounting evidence on the importance of some biological processes in tumor growth, such as vascular supply, apoptosis, autophagy, and senescence. We have investigated these processes in polymorphous low-grade adenocarcinoma (PLGA), in an attempt to identify those that are relevant for this particular lesion. We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence. Our results showed that PLGA growth does not depend on newly formed vessels but only on preexisting vasculature. Furthermore, PLGA is promoted by autophagy, sustained by both anti-apoptotic and anti-senescence signals, and stimulated by Bcl-2 and survivin.
越来越多的证据表明某些生物学过程在肿瘤生长中具有重要性，如血管供应、细胞凋亡、自噬和衰老。我们已在多形性低度腺癌（PLGA）中研究了这些过程，试图确定与这种特定病变相关的过程。我们使用免疫组织化学分析了31例PLGA，检测针对CD34和CD105的抗体以检测血管；针对D2-40的抗体以检测淋巴管；针对Bax、Bcl-2和survivin的抗体以探索细胞凋亡；针对Beclin和LCB3的抗体以研究自噬；针对p21和p16的抗体以评估衰老。我们的结果表明，PLGA的生长不依赖于新形成的血管，而仅依赖于预先存在的脉管系统。此外，自噬促进PLGA生长，抗凋亡和抗衰老信号维持其生长，并受到Bcl-2和survivin的刺激。
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