Porcheri Cristina, Meisel Christian T, Mitsiadis Thimios A
Orofacial Development and Regeneration, Institute of Oral Biology, University of Zurich, Plattenstrasse 11, 8032 Zurich, Switzerland.
Cancers (Basel). 2020 Oct 24;12(11):3107. doi: 10.3390/cancers12113107.
Salivary gland tumors are neoplasms affecting the major and minor salivary glands of the oral cavity. Their complex pathological appearance and overlapping morphological features between subtypes, pose major challenges in the identification, classification, and staging of the tumor. Recently developed techniques of three-dimensional culture and organotypic modelling provide useful platforms for the clinical and biological characterization of these malignancies. Additionally, new advances in genetic and molecular screenings allow precise diagnosis and monitoring of tumor progression. Finally, novel therapeutic tools with increased efficiency and accuracy are emerging. In this review, we summarize the most common salivary gland neoplasms and provide an overview of the state-of-the-art tools to model, diagnose, and treat salivary gland tumors.
涎腺肿瘤是影响口腔大、小涎腺的肿瘤。它们复杂的病理表现以及各亚型之间形态特征的重叠，给肿瘤的识别、分类和分期带来了重大挑战。最近开发的三维培养和器官型建模技术为这些恶性肿瘤的临床和生物学特征研究提供了有用的平台。此外，基因和分子筛查方面的新进展使肿瘤进展的精确诊断和监测成为可能。最后，效率和准确性更高的新型治疗工具正在不断涌现。在这篇综述中，我们总结了最常见的涎腺肿瘤，并概述了用于涎腺肿瘤建模、诊断和治疗的最新技术。
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