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Sox2 依赖的 p21 抑制与子宫内膜癌的不良预后相关。

Sox2-dependent inhibition of p21 is associated with poor prognosis of endometrial cancer.

作者信息

Yamawaki Kaoru, Ishiguro Tatsuya, Mori Yutaro, Yoshihara Kosuke, Suda Kazuaki, Tamura Ryo, Yamaguchi Masayuki, Sekine Masayuki, Kashima Katsunori, Higuchi Masaya, Fujii Masahiro, Okamoto Koji, Enomoto Takayuki

机构信息

Department of Obstetrics and Gynecology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

Department of Virology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.

出版信息

Cancer Sci. 2017 Apr;108(4):632-640. doi: 10.1111/cas.13196. Epub 2017 Apr 19.

DOI:10.1111/cas.13196
PMID:28188685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5406528/
Abstract

Sex-determining region Y-box 2 (SOX2) is an essential factor involved in the self-renewal and pluripotency of embryonic stem cells and has functions in cell survival and progression in many types of cancers. Here, we found that several endometrial cancer cell lines expressed SOX2, which was required for cell growth. Additionally, SOX2 overexpression regulated the expression of cyclin-dependent kinase inhibitor 1A (CDKN1A), and SOX2 specifically bound to p21 promoter DNA in endometrial cancer cell lines expressing SOX2. Expressions of SOX2 in endometrial cancer patients were significantly correlated with histological grade and poor prognosis. Moreover, low p21 together with high SOX2 expressions in advanced endometrial cancer patients were associated with the most unfavorable outcomes of patients. These results indicated that simultaneous measurement of SOX2 and p21 expression in endometrial cancer patients may be a useful biomarker for patient prognosis.

摘要

性别决定区Y框蛋白2（SOX2）是参与胚胎干细胞自我更新和多能性的重要因子，在多种癌症的细胞存活和进展中发挥作用。在此，我们发现几种子宫内膜癌细胞系表达SOX2，其为细胞生长所必需。此外，SOX2过表达调节细胞周期蛋白依赖性激酶抑制剂1A（CDKN1A）的表达，并且在表达SOX2的子宫内膜癌细胞系中，SOX2特异性结合至p21启动子DNA。SOX2在子宫内膜癌患者中的表达与组织学分级及预后不良显著相关。此外，晚期子宫内膜癌患者中低p21与高SOX2表达与患者最不利的结局相关。这些结果表明，同时检测子宫内膜癌患者中SOX2和p21的表达可能是一种用于患者预后的有用生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/e10184b6f124/CAS-108-632-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/0db367aca0f3/CAS-108-632-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/f7d46f37891f/CAS-108-632-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/329a0f5ee579/CAS-108-632-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/c072cf5fe466/CAS-108-632-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/dd92d4afbb2b/CAS-108-632-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/e10184b6f124/CAS-108-632-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/0db367aca0f3/CAS-108-632-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/f7d46f37891f/CAS-108-632-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/329a0f5ee579/CAS-108-632-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/c072cf5fe466/CAS-108-632-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/dd92d4afbb2b/CAS-108-632-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2875/5406528/e10184b6f124/CAS-108-632-g006.jpg

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2
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3
Establishment and Characterization of an In Vitro Model of Ovarian Cancer Stem-like Cells with an Enhanced Proliferative Capacity.
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4
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5
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PLoS One. 2021 Nov 3;16(11):e0259330. doi: 10.1371/journal.pone.0259330. eCollection 2021.
6
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Cell Mol Life Sci. 2021 May;78(10):4507-4519. doi: 10.1007/s00018-021-03797-8. Epub 2021 Apr 21.
7
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Cancers (Basel). 2021 Mar 29;13(7):1574. doi: 10.3390/cancers13071574.
8
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9
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10
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4
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5
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6
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7
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8
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9
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10
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